STK11 gene

Known as: serine/threonine kinase 11, LKB1, Serine/Threonine Kinase 11 Gene 
This gene plays a role in cell cycle regulation. It is also putatively involved in glucose production.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
0102019982018

Papers overview

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Highly Cited
2007
Highly Cited
2007
Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz-Jeghers syndrome, characterized by… (More)
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Highly Cited
2006
Highly Cited
2006
LKB1 is a tumor suppressor that may also be fundamental to cell metabolism, since LKB1 phosphorylates and activates the energy… (More)
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Highly Cited
2006
Highly Cited
2006
Recent studies indicate that the LKB1 is a key regulator of the AMP-activated protein kinase (AMPK), which plays a crucial role… (More)
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Highly Cited
2005
Highly Cited
2005
Germline mutations in the STK11 gene have been identified in 10-70% of patients with Peutz-Jeghers syndrome (PJS), an autosomal… (More)
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Highly Cited
2004
Highly Cited
2004
Activation of AMP-activated protein kinase (AMPK) by exercise and metformin is beneficial for the treatment of type 2 diabetes… (More)
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Highly Cited
2003
Highly Cited
2003
Inactivating mutations in the protein kinase LKB1 lead to a dominantly inherited cancer in humans termed Peutz-Jeghers syndrome… (More)
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2003
2003
We have documented previously somatic mutations of STK11/LKB11, the gene responsible for Peutz-Jeghers syndrome (PJS), in a small… (More)
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Highly Cited
1999
Highly Cited
1999
Germ-line mutations of LKB1 (STK11) lead to Peutz-Jeghers syndrome characterized by gastrointestinal polyps and cancer of… (More)
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Highly Cited
1999
Highly Cited
1999
Germline mutations of LKB1/Peutz-Jeghers syndrome gene predispose carriers to hamartomatous polyposis of the gastrointestinal… (More)
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Highly Cited
1998
Highly Cited
1998
Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease characterized by mucocutaneous pigmentation and hamartomatous… (More)
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