Synergistic effects of eukaryotic coexpression plasmid carrying LKB1 and FUS1 genes on lung cancer in vitro and in vivo

@article{Li2014SynergisticEO,
  title={Synergistic effects of eukaryotic coexpression plasmid carrying LKB1 and FUS1 genes on lung cancer in vitro and in vivo},
  author={Lingdong Li and Chuanjiang Yu and Jiang Chun Ren and Sujuan Ye and Wenjing Ou and Yu Wang and Weihan Yang and Guoxing Zhong and Xiang Chen and Huashan Shi and Xiaolan Su and Lijuan Chen and Wen Xue Zhu},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2014},
  volume={140},
  pages={895-907}
}
LKB1 and FUS1 are two kinds of new tumor suppressor genes as well as early-stage genes in lung cancer. Recent studies showed that LKB1 and FUS1 play important roles in lung carcinogenesis process. We hypothesized that combined gene therapy with LKB1 and FUS1 could inhibit lung cancer growth and development synergistically. In this study, two kinds of tumor suppressor genes, LKB1 and FUS1, were constructed in an eukaryotic coexpression plasmid pVITRO2, and then, we evaluated the synergistic… CONTINUE READING
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