Skip to search formSkip to main contentSkip to account menu

STAT6 protein, human

Known as: signal transducer and activator of transcription 6 protein, human, Transcription Factor IL-4 STAT, Signal Transducer and Activator of Transcription 6 
Signal transducer and activator of transcription 6 (847 aa, ~94 kDa) is encoded by the human STAT6 gene. This protein is involved in the modulation… 
National Institutes of Health

Related topics

Related topics

14 relations
DNA-Binding ProteinsGenes, RegulatorIL4 Signaling PathwaySH2 Domain

Broader (1)

STAT6 Transcription Factor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling
The anti-inflammatory drug high-dose intravenous immunoglobulin, widely used to suppress inflammation, depends on a specific α-2… 
2012
2012
Astrocytes, but Not Microglia, Rapidly Sense H2O2 via STAT6 Phosphorylation, Resulting in Cyclooxygenase-2 Expression and Prostaglandin Release
Emerging evidence has established that astrocytes, once considered passive supporting cells that maintained extracellular ion… 
2010
2010
Live Cell Imaging Reveals Continuous STAT6 Nuclear Trafficking
The STAT6 transcription factor is essential for the development of protective immunity; however, the consequences of its activity… 
Highly Cited
2008
Highly Cited
2008
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed enzyme shown to negatively regulate multiple tyrosine… 
Review
2006
Review
2006
Signaling mechanisms, interaction partners, and target genes of STAT6.
2003
2003
Protein Phosphatase 2A (PP2A) Regulates Interleukin-4-mediated STAT6 Signaling*
Interleukin-4 (IL-4) plays a pivotal role in the induction and maintenance of allergy by promoting Th2 differentiation and B cell… 
Highly Cited
2000
Highly Cited
2000
Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6.
Stat6 transcription factor is a critical mediator of IL-4-specific gene responses. Tyrosine phosphorylation is required for… 
Highly Cited
2000
Highly Cited
2000
Targeted disruption of stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven T(H)2 cell response.
The transcription factor, signal transducer and activator of transcription (Stat) 6, regulates T(H)2-lymphocyte activity by… 
1999
1999
Homologous human and murine antisense oligonucleotides targeting stat6. Functional effects on germline cepsilon transcript.
Interleukin (IL)-4 and (IL)-13 induce immunoglobulin (Ig)E synthesis via activation of the transcription factor signal transducer… 
Highly Cited
1998
Highly Cited
1998
Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6.
When human monocytes or alveolar macrophages are cultured in the presence of interleukin (IL)-4 or IL-13, the expression of the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)