SH2 Domain

Known as: SH2 Domains, src Homology Region 2 Domain 
A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH2 domain usually… (More)
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Spt6 promotes transcription elongation at many genes and functions as a histone H3 chaperone to alter chromatin structure during… (More)
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Highly Cited
2003
Highly Cited
2003
SAP (or SH2D1A), an adaptor-like molecule expressed in immune cells, is composed almost exclusively of a Src homology 2 (SH2… (More)
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Highly Cited
1999
Highly Cited
1999
Activation of lymphocytes through their antigen receptors leads to mobilization of intracellular Ca(2+) ions. This process… (More)
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Highly Cited
1998
Highly Cited
1998
X-linked lymphoproliferative syndrome (XLP) is an inherited immunodeficiency characterized by increased susceptibility to Epstein… (More)
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Highly Cited
1997
Highly Cited
1997
Eph-related receptor tyrosine kinases have been implicated in the control of axonal navigation and fasciculation. To investigate… (More)
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Highly Cited
1994
Highly Cited
1994
Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr… (More)
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Highly Cited
1994
Highly Cited
1994
The recently described focal adhesion kinase (FAK) has been implicated in signal transduction pathways initiated by cell adhesion… (More)
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Highly Cited
1994
Highly Cited
1994
SH2 domain proteins are important components of the signal transduction pathways activated by growth factor receptor tyrosine… (More)
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Highly Cited
1993
Highly Cited
1993
A phosphopeptide library was used to determine the sequence specificity of the peptide-binding sites of SH2 domains. One group of… (More)
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Highly Cited
1993
Highly Cited
1993
The crystal structure of the Src SH2 domain complexed with a high affinity 11-residue phosphopeptide has been determined at 2.7 A… (More)
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