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SH2 Domain

Known as: SH2 Domains, src Homology Region 2 Domain 
A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH2 domain usually… 
National Institutes of Health

Related topics

Related topics

50 relations
APS protein, humanAbelson Tyrosine-Protein Kinase 2, humanBCAR3 protein, humanBCR Downstream Signaling 1 Protein

Broader (1)

src Homology Domains

Papers overview

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Highly Cited
2014
Highly Cited
2014
Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K
Lucas et al. identify humans with a gain-of-function mutation in PIK3R1, encoding the p85α subunit of PI3K. The splice site… 
Highly Cited
2007
Highly Cited
2007
The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.
Spt6 promotes transcription elongation at many genes and functions as a histone H3 chaperone to alter chromatin structure during… 
Highly Cited
2006
Highly Cited
2006
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.
Glioblastoma multiforme is the most common and lethal form of primary brain cancer. Diagnosis of this advanced glioma has a poor… 
Highly Cited
2000
Highly Cited
2000
The Coiled-Coil Domain of Stat3 Is Essential for Its SH2 Domain-Mediated Receptor Binding and Subsequent Activation Induced by Epidermal Growth Factor and Interleukin-6
ABSTRACT STAT proteins are a family of latent transcription factors that mediate the response to various cytokines and growth… 
Highly Cited
1998
Highly Cited
1998
Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling*
SH2 domain proteins transmit intracellular signals initiated by activated tyrosine kinase-linked receptors. Recent three… 
Highly Cited
1995
Highly Cited
1995
Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains (*)
Src homology 2 (SH2) domains are phosphotyrosine binding modules found within many cytoplasmic proteins. A major function of SH2… 
Highly Cited
1992
Highly Cited
1992
Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and…
Protein tyrosine phosphatases (PTPases) are a family of enzymes important in cellular regulation. Characterization of two cDNAs… 
Highly Cited
1992
Highly Cited
1992
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs
ACTIVATION of receptor-linked and cytoplasmic protein tyrosine kinases is crucial in the control of normal and abnormal cell… 
Highly Cited
1992
Highly Cited
1992
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high‐affinity binding site for SH2 domains of phospholipase C gamma.
Several cytoplasmic tyrosine kinases contain a conserved, non‐catalytic stretch of approximately 100 amino acids called the src… 
Highly Cited
1991
Highly Cited
1991
A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases
THE phosphorylation of proteins at tyrosine residues is critical in cellular signal transduction, neoplastic transformation and… 
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