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SH2 Domain

Known as: SH2 Domains, src Homology Region 2 Domain 
A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH2 domain usually… 
National Institutes of Health

Related topics

Related topics

50 relations
APS protein, humanAbelson Tyrosine-Protein Kinase 2, humanBCAR3 protein, humanBCR Downstream Signaling 1 Protein

Broader (1)

src Homology Domains

Papers overview

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Highly Cited
2007
Highly Cited
2007
Inappropriate Recruitment and Activity by the Src Homology Region 2 Domain-Containing Phosphatase 1 (SHP1) Is Responsible for Receptor Dominance in the SHIP-Deficient NK Cell1
We have previously demonstrated that the NKR repertoire is profoundly disrupted by SHIP deficiency. This repertoire disruption is… 
Highly Cited
1999
Highly Cited
1999
Negative regulation of myeloid cell proliferation and function by the SH2 domain-containing tyrosine phosphatase-1.
The SH2 domain containing tyrosine phosphatase SHP-1 has been implicated in the regulation of a multiplicity of signaling… 
Highly Cited
1999
Highly Cited
1999
Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: dissection of the phosphopeptide sequence specificity and coupling energetics.
SH2 domains are protein modules which interact with specific tyrosine phosphorylated sequences in target proteins. The SH2 domain… 
Highly Cited
1997
Highly Cited
1997
PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor.
Insulin stimulation results in a considerable spectrum of cellular responses, only part of which have been firmly correlated with… 
Highly Cited
1996
Highly Cited
1996
In Vivo Association of v-Abl with Shc Mediated by a Non-phosphotyrosine-dependent SH2 Interaction (*)
A necessary downstream element of Abelson murine leukemia virus (Ab-MLV)-mediated transformation is Ras, which can be activated… 
Highly Cited
1994
Highly Cited
1994
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
1994
1994
Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells.
Proteins that bind to discrete domains of the Blk, Fyn, Lyn, and Btk protein tyrosine kinases were examined in pre-B cells that… 
Highly Cited
1993
Highly Cited
1993
Inhibition of the activity of protein tyrosine phosphate 1C by its SH2 domains.
Full-length protein tyrosine phosphatase 1C (PTP1C), the catalytic domain of PTP1C (delta PTP1C), and the N-terminal SH2 domain… 
Highly Cited
1993
Highly Cited
1993
In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase
We have used a transient expression system and mutant platelet-derived growth factor (PDGF) receptors to study the binding… 
1992
1992
Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6).
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