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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
TLDR
It is shown that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. Expand
Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes.
TLDR
Measurement of the expression of six genes is sufficient to predict overall survival in diffuse large-B-cell lymphoma. Expand
Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma
TLDR
The eradication of human NHL solely with a monoclonal antibody therapy combining rituximab with a blocking anti-CD47 antibody, which synergized through a mechanism combining Fc receptor (FcR)-dependent and FcR-independent stimulation of phagocytosis that might be applicable to many other cancers. Expand
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas
TLDR
These analyses identified highly recurrent epigenetic factor mutations in TET2, DNMT3A and IDH2 as well as a new highly prevalent RHOA mutation encoding a p.Gly17Val alteration, an effect potentially mediated by the sequestration of activated guanine-exchange factor (GEF) proteins. Expand
Transformation of follicular lymphoma.
TLDR
This chapter presents a state of the art review summarizing the definition of histologic transformation, its incidence, pathogenesis, clinical manifestations, treatment and outcome, and specifically emphasize gaps in knowledge that should be addressed in future studies. Expand
Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma.
TLDR
Oral lenalidomide monotherapy is active in relapsed or refractory aggressive NHL, with manageable side effects, in a phase II, single-arm, multicenter trial. Expand
Extranodal marginal zone lymphoma of the ocular adnexa.
TLDR
A state-of-the-art summary of ocular adnexal MALT lymphomas is presented, especially monoclonal antibody therapy and antibiotic therapy against Chlamydia psittaci, which has been associated with the pathogenesis of ophthalmic lymphomas in some parts of the world. Expand
Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas.
TLDR
Although an important component of the biology of a malignant cell is inherited from its nontransformed cellular progenitor-GC centroblasts-aberrant miRNA expression is acquired upon cell transformation, expression of some of the miRNAs in this signature is correlated with clinical outcome of uniformly treated DLBCL patients. Expand
Phase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas.
TLDR
The novel AAK inhibitor alisertib seems clinically active in both B- and T-cell aggressive lymphomas, and confirmatory single-agent and combination studies have been initiated. Expand
The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile.
TLDR
The validity of subdividing DLBCL into 2 major subgroups by gene expression profiling is supported, with the t(14;18) being an important event in the pathogenesis of a subset ofDLBCL arising from germinal center B cells. Expand
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