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STAT protein

Known as: STAT, Signal Transducer and Activator of Transcription 
A family of cytoplasmic proteins that are activated by phosphorylation in response to a large number of cytokines, growth factors, and hormones. They… 
National Institutes of Health

Related topics

Related topics

12 relations
STAT family geneSTAT1 protein, humanSTAT2 Transcription FactorSTAT4 protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Inhibiting aberrant Stat3 function with molecular therapeutics: a progress report
Aberrantly activated signal transducer and activator of transcription 3 (Stat3) protein plays a master regulatory role in the… 
Highly Cited
2009
Highly Cited
2009
Physical Requirements and Functional Consequences of Complex Formation between the Cytomegalovirus IE1 Protein and Human STAT2
ABSTRACT Our previous work has shown that efficient evasion from type I interferon responses by human cytomegalovirus (hCMV… 
Highly Cited
2009
Highly Cited
2009
Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo
Protein tyrosine kinases of the Janus kinase (JAK) family are associated with many cytokine receptors, which, on ligand binding… 
Highly Cited
2005
Highly Cited
2005
Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells.
Elevated epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) signaling are known to contribute to… 
Highly Cited
2003
Highly Cited
2003
Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5.
Signal transducer and activator of transcription 5 (Stat5) plays a critical role in prolactin (PRL)-induced transcription of… 
Highly Cited
2003
Highly Cited
2003
The Thanatophoric Dysplasia Type II Mutation Hampers Complete Maturation of Fibroblast Growth Factor Receptor 3 (FGFR3), Which Activates Signal Transducer and Activator of Transcription 1 (STAT1…
The K650E substitution in the fibroblast growth factor receptor 3 (FGFR3) causes constitutive tyrosine kinase activity of the… 
Highly Cited
2002
Highly Cited
2002
Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA binding.
Activation of the transcription factor signal transducer and activator of transcription 3 (STAT3) requires dimerization that is… 
Highly Cited
2000
Highly Cited
2000
Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage.
The endogenous sex steroids, testosterone and beta-estradiol, play a major role in inflammatory processes. They regulate several… 
Highly Cited
2000
Highly Cited
2000
Identification of genes induced by growth hormone in rat liver using cDNA arrays.
Growth hormone (GH) is a pleiotropic cytokine that acts upon its target cells to regulate their growth, differentiation and… 
Review
1994
Review
1994
Cell signalling and the control of gene transcription.
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