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SRD5A1 gene

Known as: steroid 5 alpha-reductase 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 1, Steroid-5-Alpha-Reductase, Alpha Polypeptide 1 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 1) Gene 
This gene is involved in the metabolism of androgens.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with… Expand
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Highly Cited
2013
Highly Cited
2013
11β-Hydroxyandrostenedione (11OHA4), which is unique to the adrenal, was first isolated from human adrenal tissue in the fifties… Expand
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Highly Cited
2011
Highly Cited
2011
In the majority of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal… Expand
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Highly Cited
2010
Highly Cited
2010
Androgen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen… Expand
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Highly Cited
2009
Highly Cited
2009
Purpose: The standard systemic treatment for prostate cancer patients is androgen deprivation therapy. Although serum… Expand
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Highly Cited
2007
Highly Cited
2007
Aims: The association between the expression of androgen receptor (AR) or androgen-converting enzymes and malignant potential in… Expand
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Highly Cited
2006
Highly Cited
2006
Purpose: Prostatic dihydrotestosterone (DHT) concentration is regulated by precursors from systemic circulation and prostatic… Expand
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Highly Cited
2004
Highly Cited
2004
BackgroundRecent evidence suggests that progesterone metabolites play important roles in regulating breast cancer. Previous… Expand
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Highly Cited
2003
Highly Cited
2003
Steroid 5α‐reductase 2 (SRD5A2) catalyzes the conversion of testosterone to the more potent androgen, DHT, in the prostate. The… Expand
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Review
1993
Review
1993
In the 20 yr since it was established that impairment of dihydrotestosterone formation is the cause of a rare form of human… Expand
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