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The Alcohol Use Disorders Identification Test (AUDIT): validation of a screening instrument for use in medical settings.
The AUDIT Core Instrument is useful for early detection of hazardous or harmful drinking, while the AUDIT Clinical Instrument is better applied to identification and/or confirmation of cases of alcohol dependence.
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
A genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls identifies variants surpassing genome- wide significance in 12 independent loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.
Alcohol treatment utilization: findings from the National Epidemiologic Survey on Alcohol and Related Conditions.
Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects
The population differences demonstrate a potential for population stratification in association studies of either of these SLC6A4 polymorphisms, and could reflect either different behavioral adaptations in different populations, or random genetic drift of a behaviorally important but selectively neutral polymorphism.
Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder
Evidence is provided of a gene × environment effect of FKBP5 and childhood abuse on the risk for PTSD in AAs and in EAs that moderated the risk of PTSD that was associated with childhood abuse.
Allelic and haplotypic association of GABRA2 with alcohol dependence
- J. Covault, J. Gelernter, V. Hesselbrock, M. Nellissery, H. Kranzler
- MedicineAmerican journal of medical genetics. Part B…
- 15 August 2004
Ten single nucleotide polymorphisms spanning the coding region of this gene were examined in samples of European American subjects with alcohol dependence, and controls screened to exclude substance use disorders, which underscore the potential contribution of polymorphic variation at the GABRA2 locus to the risk for alcohol dependence.
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci
A GWAS of alcohol dependence in European-American and African-American populations, with replication in independent samples of EAs, AAs and Germans, finds a convergence of risk genes between populations, and, to a lesser extent, between psychiatric traits.
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Data indicate that long-acting naltrexone can be of benefit in the treatment of alcohol dependence and resulted in reductions in heavy drinking among treatment-seeking alcohol-dependent patients during 6 months of therapy.
Meta‐analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence
- R. Feinn, M. Nellissery, H. Kranzler
- Biology, MedicineAmerican journal of medical genetics. Part B…
- 5 February 2005
Allelic variation at 5‐HTTLPR contributes to risk for AD, with the greatest effect observed among individuals with a co‐occurring clinical feature.
Topiramate for treating alcohol dependence: a randomized controlled trial.
Topiramate is a promising treatment for alcohol dependence and can improve drinking outcomes among alcohol-dependent individuals by reducing alcohol's reinforcing effects through facilitation of gamma-aminobutyric acid function and inhibition of glutaminergic pathways in the corticomesolimbic system.