• Publications
  • Influence
Allelic and haplotypic association of GABRA2 with alcohol dependence
TLDR
Ten single nucleotide polymorphisms spanning the coding region of this gene were examined in samples of European American subjects with alcohol dependence, and controls screened to exclude substance use disorders, which underscore the potential contribution of polymorphic variation at the GABRA2 locus to the risk for alcohol dependence. Expand
Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscle
TLDR
The times and places at which N-CAM appears are consistent with its playing several distinct roles in myogenesis, synaptogenesis, and synaptic maintenance, including alignment of secondary along primary myot tubes, early interactions of axons with myotubes, and adhesion of Schwann cells to nerve terminals. Expand
Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population.
TLDR
The findings suggest that genetic variants of GABRA2 increase risk for AD in the Russian population and provide additional support to the hypothesis that polymorphic variation at the GABra2 locus plays an important role in predisposing to AD at least in European-ancestry populations. Expand
Markers in the 5′-Region of GABRG1 Associate to Alcohol Dependence and are in Linkage Disequilibrium with Markers in the Adjacent GABRA2 Gene
TLDR
Logistic regression analysis indicated that genetic elements in the GABRG1 haplotype block likely contribute to AD risk in an additive manner, whereas those in theGABRA2 haplotypes may act in a dominant manner in relation to risk of AD. Expand
Neural cell adhesion molecule (N-CAM) accumulates in denervated and paralyzed skeletal muscles.
  • J. Covault, J. Sanes
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 July 1985
TLDR
The expression of N-CAM in muscle is regulated by the muscle's state of innervation, which might, in turn, participate in regulating muscle's susceptibility to innervation. Expand
Association Between Alcoholism and γ‐Amino Butyric Acid α2 Receptor Subtype in a Russian Population
TLDR
The findings suggest that genetic variants of GABRA2 increase risk for AD in the Russian population and provide additional support to the hypothesis that polymorphic variation at the GABra2 locus plays an important role in predisposing to AD at least in European-ancestry populations. Expand
GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride
TLDR
Preliminary evidence is provided that the risk of alcoholism associated with GABRA2 alleles may be related to differences in the subjective response to alcohol. Expand
Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and a heparan sulfate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle
TLDR
J1 is associated with collagen and other fibrils in muscle and thus may be an extracellular matrix molecule employed in both the central and peripheral nervous systems. Expand
Molecular forms of N-CAM and its RNA in developing and denervated skeletal muscle
TLDR
Forms of N-CAM and its RNA in denervated muscle are similar to those seen in perinatal myofibers, suggesting that N- CAM expression is regulated at a pretranslational level. Expand
A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors
TLDR
It is shown that microRNA-directed silencing of mRNA can be attenuated by a common human polymorphism and suggested that such functional variants may be common and may help to refine the search for genes involved in complex behavioral disorders. Expand
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