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SPINT1 gene

Known as: SPINT1, MANSC2, Serine Peptidase Inhibitor, Kunitz Type 1 Gene 
This gene plays a role in the regulation of hepatocyte growth factor maturation.
National Institutes of Health

Related topics

Related topics

4 relations
Protein Degradation InhibitionRegulation of ProteolysisSPINT1 protein, humanSPINT4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment
Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers… 
2016
2016
Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer’s Disease and Amnestic Mild Cognitive Impairment
In order to conduct early therapeutic interventions for Alzheimer’s disease (AD), convenient, early diagnosis markers are… 
Highly Cited
2015
Highly Cited
2015
A Grhl2-dependent gene network controls trophoblast branching morphogenesis
Healthy placental development is essential for reproductive success; failure of the feto-maternal interface results in pre… 
2015
2015
Hepatocyte growth factor activator inhibitor type 1 maintains the assembly of keratin into desmosomes in keratinocytes by regulating protease-activated receptor 2-dependent p38 signaling.
2014
2014
Targeted proteomics pipeline reveals potential biomarkers for the diagnosis of metastatic lung cancer in pleural effusion.
The ability to discriminate lung cancer malignant pleural effusion (LC-MPE) from benign pleural effusion has profound… 
Review
2014
Review
2014
Gene Expression Correlations in Human Cancer Cell Lines Define Molecular Interaction Networks for Epithelial Phenotype
Using gene expression data to enhance our knowledge of control networks relevant to cancer biology and therapy is a challenging… 
2011
2011
Epithelial and Mesenchymal Cell Biology Membrane-Bound Serine Protease Inhibitor HAI-1 Is Required for Maintenance of Intestinal Epithelial Integrity
From the Section of Oncopathology and Regenerative Biology, * Department of Pathology and the Department of Anatomy, Faculty of… 
Highly Cited
2010
Highly Cited
2010
Molecular Pathogenesis of Genetic and Inherited Diseases Defect of Hepatocyte Growth Factor Activator Inhibitor Type 1 / Serine Protease Inhibitor , Kunitz Type 1 ( Hai-1 / Spint 1 ) Leads to…
From the Section of Oncopathology and Regenerative Biology,* Department of Pathology, the Section of Surgical Oncology and… 
2010
2010
ST14 Gene Variant and Decreased Matriptase Protein Expression Predict Poor Breast Cancer Survival
Background: Matriptase plays a role in carcinogenesis, but the role of its genetic variation or that of the hepatocyte growth… 
2003
2003
Characterization of transcripts generated from mouse hepatocyte growth factor activator inhibitor type 2 (HAI-2) and HAI-2-related small peptide (H2RSP) genes: chimeric mRNA transcribed from both HAI…
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