Skip to search formSkip to main contentSkip to account menu

SPINT1 protein, human

Known as: Hepatocyte Growth Factor Activator Inhibitor, Hepatocyte Growth Factor Activator Inhibitor Type 1, hepatocyte growth factor activator inhibitor 1, human 
Kunitz-type protease inhibitor 1 (529 aa, ~58 kDa) is encoded by the human SPINT1 gene. This protein plays a role in both growth factor signaling and… 
National Institutes of Health

Related topics

Related topics

4 relations
Extracellular SpaceGenes, RegulatorRegulation of ProteolysisSPINT1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
A Grhl2-dependent gene network controls trophoblast branching morphogenesis
Healthy placental development is essential for reproductive success; failure of the feto-maternal interface results in pre… 
2011
2011
Increased matriptase zymogen activation in inflammatory skin disorders.
Matriptase, a type 2 transmembrane serine protease, and its inhibitor hepatocyte growth factor activator inhibitor (HAI)-1 are… 
Highly Cited
2010
Highly Cited
2010
Molecular Pathogenesis of Genetic and Inherited Diseases Defect of Hepatocyte Growth Factor Activator Inhibitor Type 1 / Serine Protease Inhibitor , Kunitz Type 1 ( Hai-1 / Spint 1 ) Leads to…
From the Section of Oncopathology and Regenerative Biology,* Department of Pathology, the Section of Surgical Oncology and… 
Highly Cited
2005
Highly Cited
2005
Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) Is Required for Branching Morphogenesis in the Chorioallantoic Placenta
ABSTRACT Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-associated Kunitz-type serine proteinase… 
Highly Cited
2005
Highly Cited
2005
Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells.
Activation of single-chain, latent matriptase, a type II transmembrane serine protease, depends on the weak proteolytic activity… 
Highly Cited
2005
Highly Cited
2005
Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract.
AIM To provide the expression profile of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator… 
Highly Cited
2002
Highly Cited
2002
Functional Characterization of Kunitz Domains in Hepatocyte Growth Factor Activator Inhibitor Type 1*
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a Kunitz-type serine protease inhibitor identified as a strong… 
2000
2000
Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta
Abstract. Activation of hepatocyte growth factor (HGF) is a crucial limiting step in HGF-induced signaling pathway. The HGF… 
2000
2000
Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes.
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2) are recently discovered Kunitz-type serine… 
Highly Cited
1997
Highly Cited
1997
Purification and Cloning of Hepatocyte Growth Factor Activator Inhibitor Type 2, a Kunitz-type Serine Protease Inhibitor*
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)