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SPINT1 protein, human

Known as: Hepatocyte Growth Factor Activator Inhibitor, Hepatocyte Growth Factor Activator Inhibitor Type 1, hepatocyte growth factor activator inhibitor 1, human 
Kunitz-type protease inhibitor 1 (529 aa, ~58 kDa) is encoded by the human SPINT1 gene. This protein plays a role in both growth factor signaling and… 
National Institutes of Health

Related topics

Related topics

4 relations
Extracellular SpaceGenes, RegulatorRegulation of ProteolysisSPINT1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model
Hepatocyte growth factor activator inhibitor type 1 (HAI-1), encoded by the Spint1 gene, is a membrane-bound serine protease… 
2011
2011
Epithelial and Mesenchymal Cell Biology Membrane-Bound Serine Protease Inhibitor HAI-1 Is Required for Maintenance of Intestinal Epithelial Integrity
From the Section of Oncopathology and Regenerative Biology, * Department of Pathology and the Department of Anatomy, Faculty of… 
2010
2010
Matriptase Does Not Require Hepatocyte Growth Factor Activator Inhibitor Type-1 for Activation in an Epithelial Cell Expression Model
Matriptase is a type II transmembrane serine protease. Paradoxically, activation of this protease is thought to require its… 
2009
2009
Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is a Kunitz-type transmembrane serine proteinase inhibitor that inhibits… 
2008
2008
Expression of hepatocyte growth factor activator inhibitor type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses
Hepatocyte growth factor activator inhibitor type 1 (HAI-1)/spint-1 is a membrane-bound protease inhibitor that is thought to… 
2007
2007
Roles of Kunitz domains in the anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-bound serine proteinase inhibitor having two… 
Highly Cited
2005
Highly Cited
2005
Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells.
Activation of single-chain, latent matriptase, a type II transmembrane serine protease, depends on the weak proteolytic activity… 
2005
2005
Diverse roles of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in the growth of glioblastoma cells in vivo.
2001
2001
Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma.
Hepatocyte growth factor activator inhibitor type 1 (HAI-1), a Kunitz-type serine protease inhibitor for hepatocyte growth factor… 
2001
2001
Mouse hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2)/placental bikunin genes and their promoters.
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