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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
THE intracellular protein tyrosine kinase FAK (focal adhesion kinase) was originally identified by its high level of tyrosine phosphorylation in v-src-transformed cells1á¤-4. FAK is also highly… Expand
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
Covalent modification of histone tails is crucial for transcriptional regulation, mitotic chromosomal condensation, and heterochromatin formation. Histone H3 lysine 9 (H3-K9) methylation catalyzed by… Expand
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
Histone H3 Lys 9 (H3-K9) methylation is a crucial epigenetic mark for transcriptional silencing. G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regions and is essential… Expand
The Rab8 GTPase regulates apical protein localization in intestinal cells
A number of proteins are known to be involved in apical/basolateral transport of proteins in polarized epithelial cells. The small GTP-binding protein Rab8 was thought to regulate basolateral… Expand
Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice1
- N. Kuroda, T. Mitani, +18 authors M. Matsumoto
- Biology, Medicine
- The Journal of Immunology
- 15 February 2005
Autoimmune regulator (AIRE) gene mutation is responsible for the development of organ-specific autoimmune disease with monogenic autosomal recessive inheritance. Although Aire has been considered to… Expand
Functional dynamics of H3K9 methylation during meiotic prophase progression
Histone H3 lysine 9 (H3K9) methylation is a crucial epigenetic mark of heterochromatin formation and transcriptional silencing. G9a is a major mammalian H3K9 methyltransferase at euchromatin and is… Expand
Parthenogenetic activation of oocytes in c-mos-deficient mice
Nature 370, 68-71 (1994) FIGURE 3b and c of this Letter was an early version that should not have been published. The correct version of this figure is shown here.
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.
The gene Bcl11b, which encodes zinc finger proteins, and its paralog, Bcl11a, are associated with immune-system malignancies. We have generated Bcl11b-deficient mice that show a block at the CD4-CD8-… Expand
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking
Immunosurveillance requires the coordinated regulation of chemokines and adhesion molecules to guide immune cell migration. However, the critical molecule for governing the high trafficking… Expand
Meikin is a conserved regulator of meiosis-I-specific kinetochore function
The kinetochore is the crucial apparatus regulating chromosome segregation in mitosis and meiosis. Particularly in meiosis I, unlike in mitosis, sister kinetochores are captured by microtubules… Expand