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SPDEF wt Allele

Known as: RP11-375E1__A.3, SAM Pointed Domain Containing ets Transcription Factor wt Allele, PDEF 
Human SPDEF wild-type allele is located in the vicinity of 6p21.3 and is approximately 19 kb in length. This allele, which encodes SAM pointed domain… 
National Institutes of Health

Related topics

Related topics

6 relations
6p21.3Androgen Receptor Regulation PathwayCell Fate ControlHomo sapiens

Papers overview

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2012
2012
Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways
BackgroundThe root bark of Paeonia suffruticosa Andrews (PSE), also known as Moutan Cortex, has been widely used in Asia to treat… 
Review
2012
Review
2012
PDEF in Prostate Cancer
Prostate‐derived Ets factor (PDEF) is a relatively recently described member of the Ets family of transcription factors. It… 
Review
2011
Review
2011
Prostate derived ETS factor (PDEF): a putative tumor metastasis suppressor.
2009
2009
PDEF is a negative regulator of colon cancer cell growth and migration
ETS is a family of transcriptional regulators with functions in most biological processes. Dysregulated ETS factor function leads… 
2008
2008
Partial splenic embolization prior to combination therapy of interferon and ribavirin in chronic hepatitis C patients with thrombocytopenia
Aim:  A low platelet count leads to dose reduction of interferon (IFN) and is associated with failure to achieve a sustained… 
2008
2008
Prostate‐derived Ets transcription factor as a favorable prognostic marker in ovarian cancer patients
We have previously shown that ovarian tumors express prostate‐derived Ets transcription factor (PDEF). However, the precise role… 
2007
2007
Prostate-derived Ets transcription factor overexpression is associated with nodal metastasis and hormone receptor positivity in invasive breast cancer.
Prostate-derived Ets transcription factor (PDEF) has recently been associated with invasive breast cancer, but no expression… 
Highly Cited
2005
Highly Cited
2005
Novel role for PDEF in epithelial cell migration and invasion.
Cell migration and invasion are two critical cellular processes that are often deregulated during tumorigenesis. To identify… 
2005
2005
Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site.
PDEF, a prostate epithelial specific transcription factor, is a member of the Ets family of DNA binding proteins. Here we report… 
1989
1989
The Xenopus U2 gene PSE is a single, compact, element required for transcription initiation and 3' end formation.
The proximal sequence element (PSE) of a Xenopus U2 snRNA gene has been analysed by extensive local mutagenesis. The PSE is… 
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