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Reprogramming of human somatic cells to pluripotency with defined factors
TLDR
The data demonstrate that defined factors can reprogramme human cells to pluripotency, and establish a method whereby patient-specific cells might be established in culture.
Selective Blockade of MicroRNA Processing by Lin28
TLDR
The results identify Lin28 as a negative regulator of miRNA biogenesis and suggest that Lin28 may play a central role in blocking miRNA-mediated differentiation in stem cells and in certain cancers.
Derivation of embryonic germ cells and male gametes from embryonic stem cells
TLDR
It is shown that embryoid bodies support maturation of the primordial germ cells into haploid male gametes, which when injected into oocytes restore the somatic diploid chromosome complement and develop into blastocysts.
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome.
TLDR
It is demonstrated that P210bcr/abl expression can induce chronic myelogenous leukemia and retrovirus-mediated expression of the protein provides a murine model system for further analysis of the disease.
Bone marrow adipocytes as negative regulators of the hematopoietic microenvironment
TLDR
In lipoatrophic A-ZIP/F1 ‘fatless’ mice, and in mice treated with the peroxisome proliferator-activated receptor-γ inhibitor bisphenol A diglycidyl ether, marrow engraftment after irradiation is accelerated relative to wild-type or untreated mice, suggesting that antagonizing marrow adipogenesis may enhance haematopoietic recovery in clinical bone-marrow transplantation.
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