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Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
- J. Brahmer, S. Tykodi, +23 authors J. Wigginton
- The New England journal of medicine
- 28 June 2012
BACKGROUND Programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor, and one of its ligands, PD-L1, play a pivotal role in the ability of tumor cells to evade the host's immune system.… Expand
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
- E. Sato, S. Olson, +15 authors K. Odunsi
- Proceedings of the National Academy of Sciences…
- 20 December 2005
In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203-213], the presence of CD3+ tumor-infiltrating lymphocytes (TILs) was found to correlate with improved survival in epithelial ovarian… Expand
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.
The mechanisms underpinning integration of instructions that program naive CD8+ T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that interleukin-12… Expand
PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment.
- N. Obermajer, Ravikumar Muthuswamy, K. Odunsi, R. P. Edwards, P. Kalinski
- Cancer research
- 15 December 2011
Signals mediated by CXCL12 (SDF1) and its receptor CXCR4 are centrally involved in cancer progression, both directly by activating cancer cells and indirectly by inducing angiogenesis plus recruiting… Expand
Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
- N. Mavaddat, D. Barrowdale, +130 authors A. Antoniou
- Cancer Epidemiology, Biomarkers & Prevention
- 5 December 2011
Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor… Expand
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in… Expand
A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis.
- J. Shen, C. Ambrosone, R. Dicioccio, K. Odunsi, S. Lele, H. Zhao
- Medicine, Biology
- 1 October 2008
A G to C polymorphism (rs2910164) is located within the sequence of miR-146a precursor, which leads to a change from a G:U pair to a C:U mismatch in its stem region. The predicted miR-146a target… Expand
Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.
BACKGROUND Few biomarkers of ovarian cancer prognosis have been established, partly because subtype-specific associations might be obscured in studies combining all histopathological subtypes. We… Expand
Non-redundant Requirement for CXCR3 Signaling during Tumoricidal T Cell Trafficking across Tumor Vascular Checkpoints
T cell trafficking at vascular sites has emerged as a key step in antitumor immunity. Chemokines are credited with guiding the multistep recruitment of CD8+ T cells across tumor vessels. However, the… Expand
Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer
- Y. Miyahara, K. Odunsi, W. Chen, G. Peng, J. Matsuzaki, R. Wang
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 7 October 2008
Despite the important role of Th17 cells in the pathogenesis of many autoimmune diseases, their prevalence and the mechanisms by which they are generated and regulated in cancer remain unclear. Here,… Expand