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SOCS1 wt Allele

Known as: STAT Induced SH3 Protein 1 Gene, CIS1, SSI1 
Human SOCS1 wild-type allele is located in the vicinity of 16p13.13 and is approximately 2 kb in length. This allele, which encodes suppressor of… 
National Institutes of Health

Related topics

Related topics

11 relations
Cytokine SignalingCytokine Signaling ProcessGrowthGrowth Hormone Signaling Pathway

Broader (1)

SOCS1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition
The suppressors of cytokine signaling (SOCS) are inhibitors of cytokine signaling that function via the Janus kinase (JAK)/signal… 
Highly Cited
2004
Highly Cited
2004
[Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in MedB-1 mediastinal lymphoma line].
Primary mediastinal B-cell lymphoma (PMBL) is a well-defined subtype of diffuse large B-cell lymphoma. Molecular cytogenetics… 
Highly Cited
2003
Highly Cited
2003
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma.
The suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the negative regulation of several cytokine… 
Highly Cited
2001
Highly Cited
2001
The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2*
Fusion of the TEL gene on 12p13 to the JAK2 tyrosine kinase gene on 9p24 has been found in human leukemia.TEL-mediated… 
Highly Cited
2001
Highly Cited
2001
Expression of suppressors of cytokine signaling during liver regeneration.
The cytokines TNF and IL-6 play a critical role early in liver regeneration following partial hepatectomy (PH). Since IL-6… 
Highly Cited
2001
Highly Cited
2001
SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo.
Highly Cited
2000
Highly Cited
2000
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in…
Signal transducers and activators of transcription (STAT)-induced STAT inhibitor-1 [SSI-1; also known as suppressor of cytokine… 
Highly Cited
1999
Highly Cited
1999
The Arabidopsis ssi1 Mutation Restores Pathogenesis-Related Gene Expression in npr1 Plants and Renders Defensin Gene Expression Salicylic Acid Dependent
The Arabidopsis NPR1 gene was previously shown to be required for the salicylic acid (SA)– and benzothiadiazole (BTH)-induced… 
Highly Cited
1999
Highly Cited
1999
Inhibition and Restoration of Prolactin Signal Transduction by Suppressors of Cytokine Signaling*
Prolactin (PRL) has been shown to activate the cytoplasmic tyrosine kinase Janus kinase 2 (Jak2) and the subsequent recruitment… 
Highly Cited
1997
Highly Cited
1997
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
Upon the corresponding ligand's stimulation, the cytokine receptors activate several signal pathways: JAK-STAT pathway, Ras-MAP… 
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