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SOAT2 gene

Known as: SOAT2, ACAT2, STEROL O-ACYLTRANSFERASE 2 
National Institutes of Health

Related topics

Related topics

2 relations
SOAT1 genesterol O-acyltransferase 2

Papers overview

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Highly Cited
2012
Highly Cited
2012
Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation[S]
The hypothesis tested in this study was that cholesterol esterification by ACAT2 would increase cholesterol absorption efficiency… Expand
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Highly Cited
2007
Highly Cited
2007
Dietary Fat–Induced Alterations in Atherosclerosis Are Abolished by ACAT2-Deficiency in ApoB100 Only, LDLr−/− Mice
Objectives—The enzyme acyl-coenzymeA (CoA):cholesterol O-acyltransferase 2 (ACAT2) in the liver synthesizes cholesteryl esters… Expand
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Highly Cited
2005
Highly Cited
2005
Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2 Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500232-JLR200
The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify… Expand
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Highly Cited
2005
Highly Cited
2005
ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice Published, JLR Papers in Press, April 1, 2005. DOI 10.1194/jlr.M500018-JLR200
The relative contributions of ACAT2 and LCAT to the cholesteryl ester (CE) content of VLDL and LDL were measured. ACAT2… Expand
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Review
2005
Review
2005
ACAT2 Is a Target for Treatment of Coronary Heart Disease Associated With Hypercholesterolemia
The inhibition of intracellular cholesterol esterification as a means to prevent atherosclerosis has been considered to have… Expand
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Highly Cited
2004
Highly Cited
2004
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness.
Acyl CoA:cholesterol acyltransferase 1 (ACAT1) and ACAT2 are enzymes responsible for the formation of cholesteryl esters in… Expand
Highly Cited
2003
Highly Cited
2003
Compared with Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) 1 and Lecithin:Cholesterol Acyltransferase, ACAT2 Displays the Greatest Capacity to Differentiate Cholesterol from Sitosterol*
The capacity of acyl-CoA:cholesterol O-acyltransferase (ACAT) 2 to differentiate cholesterol from the plant sterol, sitosterol… Expand
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Highly Cited
2000
Highly Cited
2000
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
The importance of cholesterol ester synthesis by acyl CoA:cholesterol acyltransferase (ACAT) enzymes in intestinal and hepatic… Expand
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Highly Cited
2000
Highly Cited
2000
Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates.
Two closely related enzymes with more than 50% sequence identity have been identified that catalyze the esterification of… Expand
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Highly Cited
2000
Highly Cited
2000
ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane.
A second form of the enzyme acyl-CoA:cholesterol acyltransferase, ACAT2, has been identified. To explore the hypothesis that the… Expand
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