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SOAT2 gene

Known as: SOAT2, ACAT2, STEROL O-ACYLTRANSFERASE 2 
 
National Institutes of Health

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2 relations
SOAT1 genesterol O-acyltransferase 2

Papers overview

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2017
2017
Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2
BackgroundPreviously, it has been shown that obesity may be considered as a risk factor for breast cancer in postmenopausal women… Expand
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2017
2017
Cholesterol and fatty acids regulate cysteine ubiquitination of ACAT2 through competitive oxidation
Ubiquitin linkage to cysteine is an unconventional modification targeting protein for degradation. However, the physiological… Expand
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2015
2015
Prognostic significance of two lipid metabolism enzymes, HADHA and ACAT2, in clear cell renal cell carcinoma
Renal cell carcinoma (RCC) is one of the leading causes of cancer mortality in adults, but there is still no acknowledged… Expand
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2014
2014
Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs
Intestinal cholesterol absorption involves the chylomicron and HDL pathways and is dependent on microsomal triglyceride transfer… Expand
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2008
2008
Identification of putative active site residues of ACAT enzymes** This work was supported by National Institutes of Health Grant P01-HL-49373 to L.L.R. Published, JLR Papers in Press, May 13, 2008.
In this report, we sought to determine the putative active site residues of ACAT enzymes. For experimental purposes, a particular… Expand
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Highly Cited
2005
Highly Cited
2005
Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2 Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500232-JLR200
The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify… Expand
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Highly Cited
2003
Highly Cited
2003
Compared with Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) 1 and Lecithin:Cholesterol Acyltransferase, ACAT2 Displays the Greatest Capacity to Differentiate Cholesterol from Sitosterol*
The capacity of acyl-CoA:cholesterol O-acyltransferase (ACAT) 2 to differentiate cholesterol from the plant sterol, sitosterol… Expand
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Highly Cited
2000
Highly Cited
2000
ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane.
A second form of the enzyme acyl-CoA:cholesterol acyltransferase, ACAT2, has been identified. To explore the hypothesis that the… Expand
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Highly Cited
2000
Highly Cited
2000
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
The importance of cholesterol ester synthesis by acyl CoA:cholesterol acyltransferase (ACAT) enzymes in intestinal and hepatic… Expand
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Highly Cited
2000
Highly Cited
2000
Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates.
Two closely related enzymes with more than 50% sequence identity have been identified that catalyze the esterification of… Expand
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