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Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
TLDR
Results obtained with the in vivo study were confirmed in vitro by the inhibition of sterol synthesis in various cultured cells and rats lenses, as well as by cellular uptake of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
A study to survey susceptible genetic factors responsible for troglitazone‐associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus
TLDR
A genetic polymorphic analysis by a target gene approach in troglitazone‐treated Japanese patients with type 2 diabetes mellitus is performed to address the susceptible genetic factors responsible for the hepatotoxicity associated with this agent.
Tissue selectivity of pravastatin sodium, lovastatin and simvastatin. The relationship between inhibition of de novo sterol synthesis and active drug concentrations in the liver, spleen and testis in
TLDR
It is concluded that pravastatin exhibits a liver-selective inhibition of sterol synthesis because the agent permeates the cell membrane in the liver, but not in non-hepatic tissues.
Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse model.
TLDR
The data suggest that, in the atherosclerosis-susceptible human apoB/A-II mouse model, expression of the human api-I(M) gene does not have protective advantage over that of the apoA-I gene.
Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe.
TLDR
Results suggest that ACAT1/2 dual inhibitor pactimibe has anti-atherosclerotic potential beyond its plasma cholesterol-lowering activity.
Pravastatin sodium, an inhibitor of HMG-CoA reductase, decreases HDL cholesterol by transfer of cholesteryl ester from HDL to VLDL in Japanese white rabbits.
TLDR
The present study suggests that pravastatin lowers HDL cholesterol by transferring CE from these lipoproteins to VLDL in JW rabbits.
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi.
TLDR
A novel acyl-CoA : cholesterol acyltransferase (ACAT) inhibitor, designated epi-cochlioquinone A has been isolated from the fermentation broth of Stachybotrys bisbyi SANK 17777 and showed about 10-fold less potent inhibitory effect on plasma lecithinolesterol acyl transferase (LCAT) than on ACAT.
Enhanced metabolism of phosphatidylinositol in Candida tropicalis in association with filamentous growth caused by ethanol
TLDR
Candida tropicalis Pk 233 grows in filamentous form in ethanol‐supplemented medium, and myo‐inositol prevents the ethanol ettect, and cells, which were grown with ethanol to the log phase, exhibited an increased rate of phosphatidyl inositol turnover as judged by pulse‐chase experiments with 32Pi.
Pdx1 Expression in Irs2-deficient Mouse β-Cells Is Regulated in a Strain-dependent Manner*
TLDR
It is concluded that Pdx-1 expression in Irs2-/- mice is regulated in a strain-dependent manner, IRS2- +/- mice develop diabetes associated with β-cell growth failure even when Pdx1 expression is preserved, and P dx-1expression is preserved in severely hyperglycemic Irs 2-/- dogs with a C57BL/6 background on a high fat diet.
Lipid lowering effects of pravastatin in common marmosets.
TLDR
It is confirmed that common marmosets have serum lipid and lipoprotein profiles similar to those in humans suggesting that they are susceptible to lipid lowering effects of HMG-CoA reductase inhibitors.
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