SN 38

Known as: SN-38, SN38 cpd 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2018
020406019902018

Papers overview

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Highly Cited
2004
Highly Cited
2004
Imatinib mesylate (Gleevec, STI571) is a kinase inhibitor selective for Bcr-Abl, activated c-Kit kinases, and platelet-derived… (More)
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Highly Cited
2002
Highly Cited
2002
7-Ethyl-10-hydroxycamptothecin (SN-38) is the pharmacologically active metabolite of irinotecan, in addition to being responsible… (More)
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2002
2002
OBJECTIVE The objective of the study was to develop and validate a population pharmacokinetic model for irinotecan and 2 of its… (More)
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Highly Cited
2001
Highly Cited
2001
Breast cancer resistance protein (BCRP), an ABC half-transporter, is overexpressed in cancer cell lines selected with doxorubicin… (More)
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Highly Cited
2001
Highly Cited
2001
Overexpression of breast cancer resistance protein (BCRP) ABCG2 reportedly confers cancer cell resistance to camptothecin-based… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Hepatic uridine diphosphate glucuronosyltransferase (UGT) isoform 1A1 (UGT1A1) is primarily responsible for the… (More)
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Highly Cited
1998
Highly Cited
1998
Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients with metastatic colorectal cancer. Its… (More)
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Highly Cited
1996
Highly Cited
1996
We have investigated the conversion of the novel anti-topoisomerase I agent CPT-11 (irinotecan; 7-ethyl-10[4-(1-piperidino)-1… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Irinotecan (CPT-11) is a novel water-soluble camptothecin derivative selected for clinical testing based on its good… (More)
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Highly Cited
1991
Highly Cited
1991
It is known that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a semisynthesized derivative of… (More)
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