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SLFN11 gene

Known as: Schlafen Family Member 11 Gene, FLJ34922, SLFN11 
This gene plays a role in anti-viral defense.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress… Expand
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Highly Cited
2017
Highly Cited
2017
Small cell lung cancer is initially highly responsive to cisplatin and etoposide but in almost every case becomes rapidly… Expand
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Highly Cited
2017
Highly Cited
2017
PURPOSE PARP inhibitors (PARPi) are a novel class of small molecule therapeutics for small cell lung cancer (SCLC… Expand
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2017
2017
Small cell lung cancer (SCLC) is one of the most aggressive forms of cancer, with a 5-year survival <7%. A major barrier to… Expand
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Highly Cited
2016
Highly Cited
2016
Poly(ADP-ribose) polymerase inhibitors (PARPIs) kill cancer cells by trapping PARP1 and PARP2. Talazoparib, the most potent PARPI… Expand
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2016
2016
High expression levels of SLFN11 correlate with the sensitivity of human cancer cells to DNA-damaging agents. However, little is… Expand
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2016
2016
Platinum-derived drugs such as cisplatin and carboplatin are among the most commonly used cancer chemotherapy drugs, but very few… Expand
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2015
2015
PURPOSE To determine the pharmacokinetics and the antitumor activity in pediatric cancer models of MM-398, a nanoliposomal… Expand
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2015
2015
PURPOSE SLFN11 was identified as a critical determinant of response to DNA-targeted therapies by analyzing gene expression and… Expand
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Highly Cited
2012
Highly Cited
2012
DNA-damaging agents (DDAs) constitute the backbone of treatment for most human tumors. Here we used the National Cancer Institute… Expand
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