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SLFN11 gene

Known as: Schlafen Family Member 11 Gene, FLJ34922, SLFN11 
This gene plays a role in anti-viral defense.
National Institutes of Health

Related topics

Related topics

2 relations
Antiviral ResponseImmune System Processes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
SLFN11: a new synthetic lethal target?
2018
2018
Sleep better on combination therapy: SLFN11 predicts response to veliparib and temozolomide in recurrent small cell lung cancer.
Small cell lung cancer (SCLC) is a devastating disease with rapid progression and limited treatment options (1). Topotecan is the… 
2018
2018
Abstract 4855: Indotecan (LMP400), Imidotecan (LMP776) and LMP744: A new class of non-camptothecin TOP1 inhibitors selective for cancer cells with homologous recombination deficiencies and high…
To relax DNA supercoiling, topoisomerase I (TOP1) induces DNA cleavage complexes (TOP1cc). These TOP1cc can be trapped by… 
2017
2017
A biomarker-guided approach to combining PARP inhibitors with radiotherapy in pediatric solid tumors.
10556Background: Ewing sarcoma (EWS) expresses high levels of Schlafen-11 (SLFN11). SLFN11 disrupts checkpoint maintenance and… 
2016
2016
Abstract 3870: SLFN11 is a biomarker of sensitivity to PARP inhibition and chemotherapy in small cell lung cancer (SCLC)
Small cell lung cancer (SCLC) is an aggressive disease that accounts for 14% of lung cancers. Very little progress has been made… 
2016
2016
Ausschlafen am Wochenende senkt das Diabetesrisiko
  • Mut
  • MMW - Fortschritte der Medizin
  • 2016
  • Corpus ID: 195342654
_ Wenig Schlaf reduziert die Insulinsensitivität. Wer Schlafdefizite am Wochenende gut kompensiert, normalisiert auch wieder die… 
2016
2016
Abstract 4187: Loss of SLFN11 or gain of TWIST1 promote chemotherapy resistance in small cell lung cancer
2016
2016
Hormone, Schlaf, zirkadiane Rhythmen und metabolische Gesundheit
ZusammenfassungHintergrundIn unserer modernen 24-Stunden-Gesellschaft schlafen wir durchschnittlich immer weniger und unregelm… 
2015
2015
Preclinical Activity of MM-398 , Nanoliposomal Irinotecan ( nal-IRI ) , in Ewing ' s Family Tumor Xenografts Is Associated with High Exposure of Tumor to Drug and High SLFN 11 Expression
Purpose: To determine the pharmacokinetics and the antitumor activity in pediatric cancer models of MM-398, a nanoliposomal… 
2013
2013
Wenig Schlaf, viel Schmerz: Hyperalgesie durch Schlafmangel
Schmerzpatienten schlafen aufgrund ihrer Schmerzen oft schlecht. Es gibt aber auch Hinweise, dass Schlafmangel die… 
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