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SLC4A3 gene

Known as: solute carrier family 4 member 3, Solute Carrier Family 4, Anion Exchanger, Member 3 Gene, AE3 
This gene is involved in mediating chloride/bicarbonate exchange in cardiac myocytes.
National Institutes of Health

Related topics

Related topics

7 relations
Acid-Base EquilibriumHomo sapiensIonophore activityLigand Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Emerging therapeutic targets in the short QT syndrome
ABSTRACT Introduction: Short QT Syndrome (SQTS) is a rare but dangerous condition characterised by abbreviated repolarisation… 
Highly Cited
2011
Highly Cited
2011
A Frameshift Mutation in Golden Retriever Dogs with Progressive Retinal Atrophy Endorses SLC4A3 as a Candidate Gene for Human Retinal Degenerations
Progressive retinal atrophy (PRA) in dogs, the canine equivalent of retinitis pigmentosa (RP) in humans, is characterised by… 
Highly Cited
2006
Highly Cited
2006
Mice with a Targeted Disruption of the Cl−/HCO3− Exchanger AE3 Display a Reduced Seizure Threshold
ABSTRACT Neuronal activity results in significant pH shifts in neurons, glia, and interstitial space. Several transport… 
2003
2003
Transport activity of chimaeric AE2-AE3 chloride/bicarbonate anion exchange proteins.
Chloride/bicarbonate anion exchangers (AEs), found in the plasma membrane of most mammalian cells, are involved in pH regulation… 
Highly Cited
2002
Highly Cited
2002
Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy
1995
1995
Conservation of an AE3 Cl-/HCO3- exchanger cardiac-specific exon and promoter region and AE3 mRNA expression patterns in murine and human hearts.
A cardiac-specific variant of the rat AE3 Cl-/HCO3- exchanger mRNA is transcribed from a promoter located in the sixth intron of… 
Highly Cited
1994
Highly Cited
1994
Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.
Cl-/HCO3- exchange contributes to regulation of pHi and [Cl-] in cardiac muscle, with possible effects on excitability and… 
1994
1994
Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36.
A human clone corresponding to the gene encoding anion exchanger isoform 3 (AE3) (approved gene symbol SLC2C) has been isolated… 
Highly Cited
1993
Highly Cited
1993
Cl−/HCO3 − exchange function differs in adult and fetal rat hippocampal neurons
1993
1993
Generation of truncated brain AE3 isoforms by alternate mRNA processing.
AE3 gene is a member of the AE anion exchanger gene family that is expressed primarily in brain and heart. The principal product… 
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