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SLC4A3 gene

Known as: solute carrier family 4 member 3, Solute Carrier Family 4, Anion Exchanger, Member 3 Gene, AE3 
This gene is involved in mediating chloride/bicarbonate exchange in cardiac myocytes.
National Institutes of Health

Related topics

Related topics

7 relations
Acid-Base EquilibriumHomo sapiensIonophore activityLigand Binding
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
A Frameshift Mutation in Golden Retriever Dogs with Progressive Retinal Atrophy Endorses SLC4A3 as a Candidate Gene for Human Retinal Degenerations
Progressive retinal atrophy (PRA) in dogs, the canine equivalent of retinitis pigmentosa (RP) in humans, is characterised by… Expand
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Highly Cited
2006
Highly Cited
2006
Mice with a Targeted Disruption of the Cl−/HCO3− Exchanger AE3 Display a Reduced Seizure Threshold
ABSTRACT Neuronal activity results in significant pH shifts in neurons, glia, and interstitial space. Several transport… Expand
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2003
2003
Transport activity of chimaeric AE2-AE3 chloride/bicarbonate anion exchange proteins.
Chloride/bicarbonate anion exchangers (AEs), found in the plasma membrane of most mammalian cells, are involved in pH regulation… Expand
1999
1999
Mutational analysis of the anion exchanger 3 gene in familial paroxysmal dystonic choreoathetosis linked to chromosome 2q.
Familial paroxysmal dystonic choreoathetosis (PDC) is an autosomal dominant neurological disorder characterized by episodes of… Expand
1998
1998
Further localization of a gene for paroxysmal dystonic choreoathetosis to a 5-cM region on chromosome 2q34
Abstract Paroxysmal dystonic choreoathetosis (PDC) is a rare neurological disorder characterized by episodes of involuntary… Expand
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1995
1995
Conservation of an AE3 Cl-/HCO3- exchanger cardiac-specific exon and promoter region and AE3 mRNA expression patterns in murine and human hearts.
A cardiac-specific variant of the rat AE3 Cl-/HCO3- exchanger mRNA is transcribed from a promoter located in the sixth intron of… Expand
Highly Cited
1994
Highly Cited
1994
Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.
Cl-/HCO3- exchange contributes to regulation of pHi and [Cl-] in cardiac muscle, with possible effects on excitability and… Expand
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1994
1994
Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36.
A human clone corresponding to the gene encoding anion exchanger isoform 3 (AE3) (approved gene symbol SLC2C) has been isolated… Expand
Highly Cited
1993
Highly Cited
1993
Cl−/HCO3 − exchange function differs in adult and fetal rat hippocampal neurons
We studied Cl-/HCO3- exchange function in acutely dissociated single hippocampal neurons from adult and fetal day 18 rat using a… Expand
1993
1993
Generation of truncated brain AE3 isoforms by alternate mRNA processing.
AE3 gene is a member of the AE anion exchanger gene family that is expressed primarily in brain and heart. The principal product… Expand
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