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SLC4A3 gene

Known as: solute carrier family 4 member 3, Solute Carrier Family 4, Anion Exchanger, Member 3 Gene, AE3 
This gene is involved in mediating chloride/bicarbonate exchange in cardiac myocytes.
National Institutes of Health

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Related topics

7 relations
Acid-Base EquilibriumHomo sapiensIonophore activityLigand Binding
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Papers overview

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2011
2011
A Frameshift Mutation in Golden Retriever Dogs with Progressive Retinal Atrophy Endorses SLC4A3 as a Candidate Gene for Human Retinal Degenerations
Progressive retinal atrophy (PRA) in dogs, the canine equivalent of retinitis pigmentosa (RP) in humans, is characterised by… Expand
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2011
2011
The human epithelial carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in addition to neoplastic mucins.
The term human epithelial carcinoma antigen (HCA) has been applied collectively to mucin-type high molecular weight (>1000kDa… Expand
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2008
2008
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
To analyze the cardiac functions of AE3, we disrupted its gene (Slc4a3) in mice. Cl(-)/HCO3(-) exchange coupled with Na… Expand
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Highly Cited
2006
Highly Cited
2006
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
Neuronal activity results in significant pH shifts in neurons, glia, and interstitial space. Several transport mechanisms are… Expand
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2006
2006
Involvement of AE3 isoform of Na(+)-independent Cl(-)/HCO(3)(-) exchanger in myocardial pH(i) recovery from intracellular alkalization.
Myocardial pH(i) recovery from intracellular alkalization results in part from the acid load (-J(H+)) carried by Cl(-)/HCO(3… Expand
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2002
2002
Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy
Genetic factors play a major role in the etiology of idiopathic generalized epilepsies (IGE). Our recent genome-wide search… Expand
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1999
1999
Mutational analysis of the anion exchanger 3 gene in familial paroxysmal dystonic choreoathetosis linked to chromosome 2q.
Familial paroxysmal dystonic choreoathetosis (PDC) is an autosomal dominant neurological disorder characterized by episodes of… Expand
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1995
1995
Conservation of an AE3 Cl-/HCO3- exchanger cardiac-specific exon and promoter region and AE3 mRNA expression patterns in murine and human hearts.
A cardiac-specific variant of the rat AE3 Cl-/HCO3- exchanger mRNA is transcribed from a promoter located in the sixth intron of… Expand
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Highly Cited
1994
Highly Cited
1994
Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.
Cl-/HCO3- exchange contributes to regulation of pHi and [Cl-] in cardiac muscle, with possible effects on excitability and… Expand
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1993
1993
Cl−/HCO3− exchange function differs in adult and fetal rat hippocampal neurons
We studied Cl-/HCO3- exchange function in acutely dissociated single hippocampal neurons from adult and fetal day 18 rat using a… Expand
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