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SLC4A3 gene
Known as:
solute carrier family 4 member 3
, Solute Carrier Family 4, Anion Exchanger, Member 3 Gene
, AE3
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This gene is involved in mediating chloride/bicarbonate exchange in cardiac myocytes.
National Institutes of Health
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Related topics
Related topics
7 relations
Acid-Base Equilibrium
Homo sapiens
Ionophore activity
Ligand Binding
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Emerging therapeutic targets in the short QT syndrome
J. Hancox
,
Dominic G. Whittaker
,
C. Du
,
A. G. Stuart
,
Henggui Zhang
Expert opinion on therapeutic targets
2018
Corpus ID: 13824122
ABSTRACT Introduction: Short QT Syndrome (SQTS) is a rare but dangerous condition characterised by abbreviated repolarisation…
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Highly Cited
2011
Highly Cited
2011
A Frameshift Mutation in Golden Retriever Dogs with Progressive Retinal Atrophy Endorses SLC4A3 as a Candidate Gene for Human Retinal Degenerations
L. Downs
,
Berit Wallin-Håkansson
,
+7 authors
C. Mellersh
PLoS ONE
2011
Corpus ID: 18113737
Progressive retinal atrophy (PRA) in dogs, the canine equivalent of retinitis pigmentosa (RP) in humans, is characterised by…
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Highly Cited
2006
Highly Cited
2006
Mice with a Targeted Disruption of the Cl−/HCO3− Exchanger AE3 Display a Reduced Seizure Threshold
M. Hentschke
,
M. Wiemann
,
+6 authors
C. Hübner
Molecular and Cellular Biology
2006
Corpus ID: 22672966
ABSTRACT Neuronal activity results in significant pH shifts in neurons, glia, and interstitial space. Several transport…
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2003
2003
Transport activity of chimaeric AE2-AE3 chloride/bicarbonate anion exchange proteins.
J. Fujinaga
,
Frederick B. Loiselle
,
J. Casey
Biochemical Journal
2003
Corpus ID: 21861026
Chloride/bicarbonate anion exchangers (AEs), found in the plasma membrane of most mammalian cells, are involved in pH regulation…
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Highly Cited
2002
Highly Cited
2002
Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy
T. Sander
,
M. Toliat
,
+6 authors
P. Nürnberg
Epilepsy Research
2002
Corpus ID: 44877912
1995
1995
Conservation of an AE3 Cl-/HCO3- exchanger cardiac-specific exon and promoter region and AE3 mRNA expression patterns in murine and human hearts.
S. Linn
,
G. R. Askew
,
A. Menon
,
G. Shull
Circulation Research
1995
Corpus ID: 24900678
A cardiac-specific variant of the rat AE3 Cl-/HCO3- exchanger mRNA is transcribed from a promoter located in the sixth intron of…
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Highly Cited
1994
Highly Cited
1994
Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.
D. Yannoukakos
,
A. Stuart-Tilley
,
H. A. Fernandez
,
P. Fey
,
G. Duyk
,
S. Alper
Circulation Research
1994
Corpus ID: 12694633
Cl-/HCO3- exchange contributes to regulation of pHi and [Cl-] in cardiac muscle, with possible effects on excitability and…
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1994
1994
Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36.
Y. R. Su
,
C. Klanke
,
+7 authors
A. Menon
Genomics
1994
Corpus ID: 43473556
A human clone corresponding to the gene encoding anion exchanger isoform 3 (AE3) (approved gene symbol SLC2C) has been isolated…
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Highly Cited
1993
Highly Cited
1993
Cl−/HCO3 − exchange function differs in adult and fetal rat hippocampal neurons
K. Raley-Susman
,
R. Sapolsky
,
R. Kopito
Brain Research
1993
Corpus ID: 24669676
1993
1993
Generation of truncated brain AE3 isoforms by alternate mRNA processing.
C. Morgans
,
R. Kopito
Journal of Cell Science
1993
Corpus ID: 43403105
AE3 gene is a member of the AE anion exchanger gene family that is expressed primarily in brain and heart. The principal product…
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