FAQ

SLC4A3 gene

Known as: solute carrier family 4 member 3, Solute Carrier Family 4, Anion Exchanger, Member 3 Gene, AE3 
This gene is involved in mediating chloride/bicarbonate exchange in cardiac myocytes.

Topic mentions per year

Topic mentions per year

1986-2018
02419862018

Related topics

Related topics

6 relations
Acid-Base EquilibriumHomo sapiensIonophore activityLigand Binding
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
SLC4A3 gene
Homo sapiens
Transmembrane Transport
Acid-Base Equilibrium
Ligand Binding
Ionophore activity

Papers overview

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2011
2011
A Frameshift Mutation in Golden Retriever Dogs with Progressive Retinal Atrophy Endorses SLC4A3 as a Candidate Gene for Human Retinal Degenerations
Progressive retinal atrophy (PRA) in dogs, the canine equivalent of retinitis pigmentosa (RP) in humans, is characterised by… (More)
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2011
2011
Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.
The AE3 Cl(-)/HCO(3)(-) exchanger is abundantly expressed in the sarcolemma of cardiomyocytes, where it mediates Cl(-)-uptake and… (More)
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2009
2009
NKCC1 and AE3 appear to accumulate chloride in embryonic motoneurons.
During early development, gamma-aminobutyric acid (GABA) depolarizes and excites neurons, contrary to its typical function in the… (More)
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2006
2006
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
Neuronal activity results in significant pH shifts in neurons, glia, and interstitial space. Several transport mechanisms are… (More)
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2003
2003
Differential expression pattern of chloride transporters NCC, NKCC2, KCC1, KCC3, KCC4, and AE3 in the developing rat auditory brainstem
During development of inhibitory synapses, the action of the two neurotransmitters GABA and glycine shifts from depolarizing to… (More)
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1999
1999
Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH.
Plasma membrane Cl(-)/HCO(3)(-) anion-exchange (AE) proteins contribute to regulation of intracellular pH (pH(i)). We… (More)
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1994
1994
AE3 anion exchanger isoforms in the vertebrate retina: developmental regulation and differential expression in neurons and glia.
Plasma membrane anion exchangers constitute a multigene family that contributes to the regulation of intracellular pH and… (More)
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1994
1994
Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.
Cl-/HCO3- exchange contributes to regulation of pHi and [Cl-] in cardiac muscle, with possible effects on excitability and… (More)
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1993
1993
Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin.
The 89 kDa NH2-terminal domain of erythrocyte ankyrin is composed almost entirely of 22 tandem repeats of a 33 amino acid… (More)
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1992
1992
The predicted translation product of a cardiac AE3 mRNA contains an N terminus distinct from that of the brain AE3 Cl-/HCO3- exchanger. Cloning of a cardiac AE3 cDNA, organization of the AE3 gene…
We have isolated cDNAs encoding a cardiac variant of the AE3 Cl-/HCO3- exchanger from a rat heart library. The predicted cardiac… (More)
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