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D5 (Not D1) Dopamine Receptors Potentiate Burst-Firing in Neurons of the Subthalamic Nucleus by Modulating an L-Type Calcium Conductance
Dopamine is a crucial factor in basal ganglia functioning. In current models of basal ganglia, dopamine is postulated to act on striatal neurons. However, it may also act on the subthalamic nucleusExpand
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Evidence for Inhibition Mediated by Coassembly of GABAA and GABAC Receptor Subunits in Native Central Neurons
Fast inhibition in the nervous system is commonly mediated by GABAA receptors comprised of 2α/2β/1γ subunits. In contrast, GABAC receptors containing onlyρ subunits (ρ1-ρ3) have been predominantlyExpand
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Expression of GABA Receptor ρ Subunits in Rat Brain
Abstract: The GABA receptor ρ1, ρ2, and ρ3 subunits are expressed in the retina where they form bicuculline‐insensitive GABAC receptors. We used northern blot, in situ hybridization, and RT‐PCRExpand
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Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus.
Blood-borne hormones acting in the mediobasal hypothalamus, like those controlling food intake, require relatively direct access to target chemosensory neurons of the arcuate nucleus (ARC). AnExpand
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Functional Properties of Internalization-Deficient P2X4 Receptors Reveal a Novel Mechanism of Ligand-Gated Channel Facilitation by Ivermectin
Although P2X receptors within the central nervous system mediate excitatory ATP synaptic transmission, the identity of central ATP-gated channels has not yet been elucidated. P2X4, the most widelyExpand
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Cross-talk and Co-trafficking between ρ1/GABA Receptors and ATP-gated Channels*
γ-Aminobutyric-acid (GABA) and ATP ionotropic receptors represent two structurally and functionally different classes of neurotransmitter-gated channels involved in fast synaptic transmission. WeExpand
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cDNA cloning and expression of a γ‐aminobutyric acidA receptor ε‐subunit in rat brain
A cDNA encoding a GABAA receptor subunit was isolated from rat brain. The predicted protein is 70% identical to the human ε‐subunit. It was recently reported [Sinkkonen et al. (2000), J. Neurosci.,Expand
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Localisation of GABAA receptor ϵ-subunit in cholinergic and aminergic neurones and evidence for co-distribution with the θ-subunit in rat brain
Abstract In situ hybridisation and immunohistochemical methodologies suggest the existence of a large diversity of GABA A receptor subtypes in the brain. These are hetero-oligomeric proteinsExpand
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Cross-talk between P2X4 and γ-Aminobutyric Acid, Type A Receptors Determines Synaptic Efficacy at a Central Synapse*
The essence of neuronal function is to generate outputs in response to synaptic potentials. Synaptic integration at postsynaptic sites determines neuronal outputs in the CNS. UsingExpand
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Impact of chronic subthalamic high‐frequency stimulation on metabolic basal ganglia activity: a 2‐deoxyglucose uptake and cytochrome oxidase mRNA study in a macaque model of Parkinson's disease
The mechanisms of action of high‐frequency stimulation (HFS) of the subthalamic nucleus (STN) remain only partially understood. Hitherto, experimental studies have suggested that STN‐HFS reduces theExpand
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