SIRT6 gene

Known as: SIRT6, SIRTUIN 6, SIR2-LIKE 6 
This gene may be involved in post-translational modification of proteins.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2017
020406020032017

Papers overview

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Highly Cited
2012
Highly Cited
2012
The significant increase in human lifespan during the past century confronts us with great medical challenges. To meet these… (More)
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Highly Cited
2012
Highly Cited
2012
Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the… (More)
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Highly Cited
2011
Highly Cited
2011
Sirtuin 6 (SIRT6) is a mammalian homolog of the yeast Sir2 deacetylase. Mice deficient for SIRT6 exhibit genome instability. Here… (More)
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Highly Cited
2010
Highly Cited
2010
SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress… (More)
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Highly Cited
2010
Highly Cited
2010
SIRT6 belongs to the sirtuin family of protein lysine deacetylases, which regulate aging and genome stability. We found that… (More)
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Highly Cited
2010
Highly Cited
2010
Under various conditions, mammals have the ability to maintain serum glucose concentration within a narrow range. SIRT1 plays an… (More)
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Highly Cited
2009
Highly Cited
2009
Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms. Deficiency of… (More)
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Highly Cited
2008
Highly Cited
2008
The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae. In mice, deficiency for the Sir2… (More)
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Highly Cited
2006
Highly Cited
2006
The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination, genomic stability, and aging in budding… (More)
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Highly Cited
2005
Highly Cited
2005
Members of the Sir2 family of NAD-dependent protein deacetylases regulate diverse cellular processes including aging, gene… (More)
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