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SHH protein, human

Known as: HHG1, Sonic Hedgehog Protein, Sonic hedgehog protein, human 
Expressed only during embryogenesis by human SHH Gene (Hedgehog Family), 462-aa 50-kDa (precursor) Sonic Hedgehog Homolog is the notochord inductive… 
National Institutes of Health

Related topics

Related topics

11 relations
Hedgehog FamilyIntercellular Communication ProcessPattern FormationPtc1 Regulation of Cell Cycle Pathway

Broader (2)

Hedgehog ProteinsSonic hedgehog protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation
ABSTRACT Gli2 and Gli3 are the primary transcription factors that mediate Sonic hedgehog (Shh) signals in the mouse. Gli3 mainly… 
Highly Cited
2000
Highly Cited
2000
Hedgehog signals regulate multiple aspects of gastrointestinal development.
The gastrointestinal tract develops from the embryonic gut, which is composed of an endodermally derived epithelium surrounded by… 
Highly Cited
1999
Highly Cited
1999
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.
Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling in vertebrates. The question remains unanswered… 
Highly Cited
1999
Highly Cited
1999
Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3*
Drosophila transcription factorcubitus interruptus (Ci) and its co-activator CRE (cAMP response element)-binding protein (CBP… 
Highly Cited
1998
Highly Cited
1998
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.
Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by… 
Highly Cited
1997
Highly Cited
1997
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
Sporadic basal cell carcinoma (BCC) is the most common type of malignant cancer in fair-skinned adults. Familial BCCs and a… 
Highly Cited
1997
Highly Cited
1997
Ectopic Pax-3 Activates MyoD and Myf-5 Expression in Embryonic Mesoderm and Neural Tissue
Highly Cited
1996
Highly Cited
1996
Biochemical evidence that Patched is the Hedgehog receptor
THE protein Sonic hedgehog (Shh) is essential for a variety of patterning events during development. It is the signal from the… 
Highly Cited
1996
Highly Cited
1996
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.
Sonic hedgehog is a secreted factor regulating patterning of the anterior-posterior axis in the developing limb. The signaling… 
Highly Cited
1995
Highly Cited
1995
Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb
FORMATION of the vertebrate limb requires specification of cell position along three axes1. Proximal–distal identity is regulated… 
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