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Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
- F. Guillemot, Li-Ching Lo, J. E. Johnson, A. Auerbach, A. Joyner
- Biology, Medicine
- 5 November 1993
The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed in neural precursors. We created a null allele of this gene by… Expand
Essential role of Mash-2 in extraembryonic development
THE outer layer of the blastocyst, or trophectoderm, is the first cell lineage to differentiate in the mouse embryo1,2, but little is known about the genetic control of its development.… Expand
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.
The Shh signaling pathway is required in many mammalian tissues for embryonic patterning, cell proliferation and differentiation. In addition, inappropriate activation of the pathway has been… Expand
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
Sonic hedgehog (Shh) has been implicated in the ongoing neurogenesis in postnatal rodent brains. Here we adopted an in vivo genetic fate-mapping strategy, using Gli1 (GLI-Kruppel family member) as a… Expand
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.
An important question is how the gradient of Hedgehog is interpreted by cells at the level of the Gli transcription factors. The full range of Gli activity and its dependence on Hh have not been… Expand
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.
The correct patterning of vertebrate skeletal elements is controlled by inductive interactions. Two vertebrate hedgehog proteins, Sonic hedgehog and Indian hedgehog, have been implicated in skeletal… Expand
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.
The secreted factor Sonic hedgehog (SHH) is both required for and sufficient to induce multiple developmental processes, including ventralization of the CNS, branching morphogenesis of the lungs and… Expand
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation
ABSTRACT Gli2 and Gli3 are the primary transcription factors that mediate Sonic hedgehog (Shh) signals in the mouse. Gli3 mainly acts as a transcriptional repressor, because the majority of… Expand
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation.
- R. Kimmel, D. H. Turnbull, V. Blanquet, W. Wurst, C. Loomis, A. Joyner
- Biology, Medicine
- Genes & development
- 1 June 2000
Proximal-distal outgrowth of the vertebrate limb bud is regulated by the apical ectodermal ridge (AER), which forms at an invariant position along the dorsal-ventral (D/V) axis of the embryo. We have… Expand
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.
Induction of the floor plate at the ventral midline of the neural tube is one of the earliest events in the establishment of dorsoventral (d/v) polarity in the vertebrate central nervous system… Expand