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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
TLDR
A large-scale screen is described to create an atlas of CNS gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosome vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways.
Essential role of Mash-2 in extraembryonic development
TLDR
Mash-2 is the first transcription factor shown to play a critical part in the development of the mammalian trophoblast lineage and rescued this placental mutant phenotype by constructing chimaeras with tetraploid wild-type embryos which contribute almost exclusively to extraembryonic tissues.
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
TLDR
Observations suggest that Mash-1, like its Drosophila homologs of the AS-C, controls a basic operation in development of neuronal progenitors in distinct neural lineages.
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.
TLDR
It is demonstrated that, in mammals, Gli1 is not required for Shh signaling and that Gli2 mediates inappropriate activation of the pathway due to loss of the negative regulator Ptc.
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.
TLDR
It is demonstrated that Gli3 can transduce Hedgehog signaling as an activator and is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors in embryos lacking all Gli function.
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
TLDR
An in vivo genetic fate-mapping strategy is adopted, using Gli1 (GLI-Kruppel family member) as a sensitive readout of Shh activity, to systematically mark and follow the fate of ShH-responding cells in the adult mouse forebrain.
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation.
TLDR
Two distinct lineage boundaries in mouse ectoderm prior to limb bud outgrowth are identified using a Cre/loxP-based fate-mapping approach and a novel retroviral cell-labeling technique and fate mapping of AER domains in mutants showed that En1 plays a part in positioning and maintaining the two lineage borders.
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.
TLDR
It is found that the floor plate throughout the midbrain, hindbrain and spinal cord does not form in Gli2 homozygotes, suggesting that early signals derived from the notochord can be sufficient for establishing the basic d/v domains of cell differentiation in the ventral spinal cord and hindbrain.
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation
TLDR
These findings provide the first demonstration of a molecular mechanism by which the Gli2 transcriptional activity is regulated by Shh signaling and in addition to being processed, Gli 2 full-length protein is readily degraded.
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.
TLDR
It is shown here that Gli2 mutant mice exhibit severe skeletal abnormalities including cleft palate, tooth defects, absence of vertebral body and intervertebral discs, and shortened limbs and sternum.
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