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SDZ PSC 833

Known as: PSC 833, SDZ-PSC-833, PSC833 
An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity… 
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (1)

Amdray

Broader (2)

Cyclosporinsvalspodar
PSC 833/vinblastinecarboplatin/paclitaxel/PSC 833cytarabine/daunorubicin/etoposide/PSC 833cytarabine/etoposide/mitoxantrone/PSC 833

Papers overview

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Highly Cited
2003
Highly Cited
2003
Atp Binding Cassette Multidrug Transporters Limit the Anti-HIV Activity of Zidovudine and Indinavir in Infected Human Macrophages
Objectives To investigate whether P-glycoprotein (P-gp) and multidrug resistance proteins (MRPs), which limit the bioavailability… 
Highly Cited
2003
Highly Cited
2003
Examination of the Functional Activity of P-glycoprotein in the Rat Placental Barrier Using Rhodamine 123
Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux… 
Highly Cited
2002
Highly Cited
2002
Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice
Abstract.Purpose: The extensive and unpredictable biliary excretion of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide… 
Highly Cited
2001
Highly Cited
2001
A phase I trial of doxorubicin, paclitaxel, and valspodar (PSC 833), a modulator of multidrug resistance.
PURPOSE P-glycoprotein is an efflux pump for many drugs including doxorubicin and paclitaxel. This study evaluated the… 
Highly Cited
2001
Highly Cited
2001
Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia.
PURPOSE To determine the maximum-tolerated dose, pharmacokinetic interaction, and activity of PSC 833 compared with daunorubicin… 
Highly Cited
2001
Highly Cited
2001
Screening of Multidrug-Resistance Sensitive Drugs by In Situ Brain Perfusion in P-Glycoprotein-Deficient Mice
AbstractPurpose. This study was conducted to assess the influence of P-glycoprotein (P-gp) on brain uptake of multidrug… 
Highly Cited
2000
Highly Cited
2000
Increased intracellular drug accumulation and complete chemosensitization achieved in multidrug‐resistant solid tumors by co‐administering valspodar (PSC 833) with sterically stabilized liposomal…
We have previously demonstrated that liposome encapsulation of doxorubicin (DOX) can alleviate adverse interactions with non… 
Highly Cited
2000
Highly Cited
2000
Biliary Excretion of 17β-Estradiol 17β-d-Glucuronide Is Predominantly Mediated by cMOAT/MRP2
AbstractPurpose. The mechanism for the biliary excretion of 17β-estradiol17β0-d-glucuronide (E217βG), a cholestatic metabolite of… 
Review
1998
Review
1998
Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors.
1995
1995
Circumvention of P‐glycoprotein‐mediated drug resistance in human leukaemic cells by non‐immunosuppressive cyclosporin D analogue, SDZ PSC 833
Summary. Cyclosporin A (CSA) exhibits greater multidrug resistance (MDR) modulating activity in vitro than other MDR modulators… 
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