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SDZ PSC 833

Known as: PSC 833, SDZ-PSC-833, PSC833 
An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity… Expand
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
Understanding mechanisms associated with flavonoid neuroprotection is complicated by the lack of information on their ability to… Expand
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Highly Cited
2003
Highly Cited
2003
Inappropriate expression of the multidrug resistance (MDR1) gene encoding the P-glycoprotein (Pgp) has been frequently implicated… Expand
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Highly Cited
2003
Highly Cited
2003
P-Glycoprotein (Pgp) in the blood-brain barrier limits the uptake of substrate drugs into the brain. We have determined the… Expand
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Highly Cited
2002
Highly Cited
2002
The Cancer and Leukemia Group B conducted a phase 3 trial of the P-glycoprotein modulator PSC-833 in untreated acute myeloid… Expand
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Highly Cited
2000
Highly Cited
2000
  • E. Choo, B. Leake, +4 authors R. Kim
  • Drug metabolism and disposition: the biological…
  • 2000
  • Corpus ID: 1655499
HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and… Expand
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Highly Cited
2000
Highly Cited
2000
To identify specific transporters that drive xenobiotics from central nervous system to blood, the accumulation of fluorescent… Expand
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Highly Cited
2000
Highly Cited
2000
Cadmium-mediated toxicity of cultured proximal tubule (PT) cells is associated with increased production of reactive oxygen… Expand
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Highly Cited
1999
Highly Cited
1999
It was recently shown that naturally occurring Mdr1a mutant fetuses of the CF-1 outbred mouse stock have no placental Mdr1a P… Expand
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Review
1997
Review
1997
Abstract Intrinsic and acquired multidrug resistance (MDR) in many human cancers may be due to expression of the multidrug… Expand
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Highly Cited
1991
Highly Cited
1991
The new nonimmunosuppressive cyclosporin analogue, SDZ PSC 833, is a very potent multidrug-resistance modifier. In vitro, it was… Expand
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