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SDZ PSC 833

Known as: PSC 833, SDZ-PSC-833, PSC833 
An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity… 
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (1)

Amdray

Broader (2)

Cyclosporinsvalspodar
PSC 833/vinblastinecarboplatin/paclitaxel/PSC 833cytarabine/daunorubicin/etoposide/PSC 833cytarabine/etoposide/mitoxantrone/PSC 833

Papers overview

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Highly Cited
2006
Highly Cited
2006
In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using [11C]Verapamil
P-glycoprotein (P-gp) is a major efflux transporter contributing to the efflux of a range of xenobiotic compounds at the blood… 
Highly Cited
2003
Highly Cited
2003
Examination of the Functional Activity of P-glycoprotein in the Rat Placental Barrier Using Rhodamine 123
Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux… 
Highly Cited
2003
Highly Cited
2003
Atp Binding Cassette Multidrug Transporters Limit the Anti-HIV Activity of Zidovudine and Indinavir in Infected Human Macrophages
Objectives To investigate whether P-glycoprotein (P-gp) and multidrug resistance proteins (MRPs), which limit the bioavailability… 
Highly Cited
2001
Highly Cited
2001
A phase I trial of doxorubicin, paclitaxel, and valspodar (PSC 833), a modulator of multidrug resistance.
PURPOSE P-glycoprotein is an efflux pump for many drugs including doxorubicin and paclitaxel. This study evaluated the… 
Highly Cited
2001
Highly Cited
2001
Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia.
PURPOSE To determine the maximum-tolerated dose, pharmacokinetic interaction, and activity of PSC 833 compared with daunorubicin… 
Highly Cited
2001
Highly Cited
2001
Screening of Multidrug-Resistance Sensitive Drugs by In Situ Brain Perfusion in P-Glycoprotein-Deficient Mice
AbstractPurpose. This study was conducted to assess the influence of P-glycoprotein (P-gp) on brain uptake of multidrug… 
Highly Cited
2000
Highly Cited
2000
P-glycoprotein and multidrug resistance protein activities in relation to treatment outcome in acute myeloid leukemia.
Despite treatment with intensive chemotherapy, a considerable number of patients with acute myeloid leukemia (AML) die from their… 
Highly Cited
2000
Highly Cited
2000
Increased intracellular drug accumulation and complete chemosensitization achieved in multidrug‐resistant solid tumors by co‐administering valspodar (PSC 833) with sterically stabilized liposomal…
We have previously demonstrated that liposome encapsulation of doxorubicin (DOX) can alleviate adverse interactions with non… 
Highly Cited
1999
Highly Cited
1999
Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells.
MDR1 P-glycoprotein (Pgp), the product of the MDR1 gene involved in multidrug resistance in cancer cells, is also expressed in… 
Review
1998
Review
1998
Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors.
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