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SDZ PSC 833

Known as: PSC 833, SDZ-PSC-833, PSC833 
An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity… 
National Institutes of Health

Related topics

Related topics

9 relations

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Broader (2)

Cyclosporinsvalspodar
PSC 833/vinblastinecarboplatin/paclitaxel/PSC 833cytarabine/daunorubicin/etoposide/PSC 833cytarabine/etoposide/mitoxantrone/PSC 833

Papers overview

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Review
2011
Review
2011
Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity.
For the last twenty years, significant progress in Molecular and Cellular Biology has resulted in a better characterization and… 
2004
2004
P‐glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells
P‐glycoprotein (P‐gp) is commonly associated with multi‐drug resistance (MDR) in cancer cells and the efflux of a broad spectrum… 
Highly Cited
2003
Highly Cited
2003
Atp Binding Cassette Multidrug Transporters Limit the Anti-HIV Activity of Zidovudine and Indinavir in Infected Human Macrophages
Objectives To investigate whether P-glycoprotein (P-gp) and multidrug resistance proteins (MRPs), which limit the bioavailability… 
Highly Cited
2003
Highly Cited
2003
Examination of the Functional Activity of P-glycoprotein in the Rat Placental Barrier Using Rhodamine 123
Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux… 
2003
2003
P‐glycoprotein (ABCB1) but not multidrug resistance‐associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes
At least two drug efflux pumps involved in multidrug resistance, P‐glycoprotein (P‐gp) and multidrug resistance‐associated… 
Highly Cited
2002
Highly Cited
2002
Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice
Abstract.Purpose: The extensive and unpredictable biliary excretion of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide… 
Highly Cited
2001
Highly Cited
2001
Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia.
PURPOSE To determine the maximum-tolerated dose, pharmacokinetic interaction, and activity of PSC 833 compared with daunorubicin… 
Highly Cited
2000
Highly Cited
2000
Increased intracellular drug accumulation and complete chemosensitization achieved in multidrug‐resistant solid tumors by co‐administering valspodar (PSC 833) with sterically stabilized liposomal…
We have previously demonstrated that liposome encapsulation of doxorubicin (DOX) can alleviate adverse interactions with non… 
Review
1998
Review
1998
Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors.
1995
1995
Circumvention of P‐glycoprotein‐mediated drug resistance in human leukaemic cells by non‐immunosuppressive cyclosporin D analogue, SDZ PSC 833
Summary. Cyclosporin A (CSA) exhibits greater multidrug resistance (MDR) modulating activity in vitro than other MDR modulators… 
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