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Cyclosporins

Known as: Cyclosporine, Cyclosporines, Cyclosporins [Chemical/Ingredient] 
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and… 
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (22)

Debio088IMM 125SCY-635SCY-641

Broader (2)

Enzyme InhibitorsImmunosuppressive Agents
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Cyclosporins. Structure-activity relationships.
Cyclosporin A (Sandimmun) achieves immunosuppressive activity by complex formation with cyclophilin and subsequent binding of the… 
Review
2004
Review
2004
Pharmacologic circumvention of multidrug resistance
The ability of malignant cells to develop resistance to chemotherapeutic drugs is a major obstacle to the successful treatment of… 
Highly Cited
2002
Highly Cited
2002
Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter.
Cyclic undecapeptide cyclo-[MeBmt(1)-Abu(2)-MeGly(3)-MeLeu(4)-Val(5)-MeLeu(6)-Ala(7)-D-Ala(8)-MeLeu(9)-MeLeu(10)-MeVal(11)], the… 
Highly Cited
2001
Highly Cited
2001
A phase I trial of doxorubicin, paclitaxel, and valspodar (PSC 833), a modulator of multidrug resistance.
PURPOSE P-glycoprotein is an efflux pump for many drugs including doxorubicin and paclitaxel. This study evaluated the… 
Review
2001
Review
2001
Cyclosporin H Is a Potent and Selective Formyl Peptide Receptor Antagonist Comparison with Nt-Butoxycarbonyl-~-phenylalanyl-L-leucyl-L-phenylalanyl-1-leucyl-L-phenylalanine and Cyclosporins
he cyclic undecapeptide, cyclosporin (Cs) H, is a potent inhibitor of FMLP-induced superoxide anion (02-) formation in human… 
Highly Cited
1989
Highly Cited
1989
Cell-free biosynthesis of new cyclosporins.
An enzyme preparation, isolated from extracts of the fungus Beauveria nivea (previously designated Tolypocladium inflatum), is… 
1989
1989
Enhancement of anthracycline growth inhibition in parent and multidrug-resistant Chinese hamster ovary cells by cyclosporin A and its analogues.
Cyclosporins have been shown to sensitize multidrug-resistant cells to chemotherapeutic agents but, generally, have minimal… 
1988
1988
The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2…
1988
1988
The insecticidal activity of cyclosporines on mosquito larvae.
Highly Cited
1987
Highly Cited
1987
The cyclosporins inhibit lymphocyte activation at more than one site.
Cyclosporin A (CsA), a potent immunosuppressive agent, acts primarily by inhibiting T cell function. Although several potential… 
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