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valspodar

Known as: valspodar [Chemical/Ingredient], 3'-keto-Bmt(1)-Val(2)-cyclosporin A, SZD PSC 833 
An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Cancer and Leukemia Group B 19808 (CALGB 19808) is the only randomized trial of a second-generation P-glycoprotein (Pgp… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE To compare the safety and efficacy of carboplatin and paclitaxel administered with or without the multidrug resistance… Expand
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Highly Cited
2007
Highly Cited
2007
The ATP-driven drug efflux pump, P-glycoprotein, is a critical and selective element of the blood-brain barrier and a primary… Expand
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Highly Cited
2006
Highly Cited
2006
At the blood-brain barrier, P-glycoprotein, an ATP-driven drug efflux pump, selectively limits drug access to the brain… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE To determine whether adding the multidrug resistance gene-1 (MDR-1) modulator valspodar (PSC 833; Novartis… Expand
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Highly Cited
2003
Highly Cited
2003
P-Glycoprotein (Pgp) in the blood-brain barrier limits the uptake of substrate drugs into the brain. We have determined the… Expand
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Review
2003
Review
2003
  • P. Vasey
  • British Journal of Cancer
  • 2003
  • Corpus ID: 9025154
Although treatment for advanced epithelial ovarian cancer has improved over recent years with the introduction of taxane–platinum… Expand
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Highly Cited
2002
Highly Cited
2002
Paclitaxel concentrations in the brain are very low after intravenous injection. Since paclitaxel is excluded from some tumors by… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE A phase II study was conducted to determine the efficacy of paclitaxel and valspodar (PSC 833) in patients with advanced… Expand
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Highly Cited
2000
Highly Cited
2000
  • E. Choo, B. Leake, +4 authors R. Kim
  • Drug metabolism and disposition: the biological…
  • 2000
  • Corpus ID: 1655499
HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and… Expand
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