valspodar

Known as: valspodar [Chemical/Ingredient], 3'-keto-Bmt(1)-Val(2)-cyclosporin A, SZD PSC 833 
An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Reduced clearance of amyloid-beta (Abeta) from brain partly underlies increased Abeta brain accumulation in Alzheimer's disease… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE To compare the safety and efficacy of carboplatin and paclitaxel administered with or without the multidrug resistance… (More)
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2007
2007
The selective protein tyrosine kinase inhibitor, imatinib, inhibits the growth of glioma cells in preclinical models, but its… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE To determine whether adding the multidrug resistance gene-1 (MDR-1) modulator valspodar (PSC 833; Novartis… (More)
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Highly Cited
2002
Highly Cited
2002
Paclitaxel concentrations in the brain are very low after intravenous injection. Since paclitaxel is excluded from some tumors by… (More)
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Review
2000
Review
2000
  • Hsin Tai
  • Current opinion in molecular therapeutics
  • 2000
Valspodar (PSC-833) is a derivative of cyclosporin but devoid of the immunosuppressive and nephrotoxic properties seen in… (More)
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Highly Cited
2000
Highly Cited
2000
HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and… (More)
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2000
2000
PURPOSE The aim of the present study was to evaluate the effect of the cyclosporine derivative valspodar (PSC 833; Amdray… (More)
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2000
2000
We have previously demonstrated that liposome encapsulation of doxorubicin (DOX) can alleviate adverse interactions with non… (More)
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1999
1999
OBJECTIVES Valspodar is a P-glycoprotein modulator currently under development as a multidrug resistance reversal agent in… (More)
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