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SCH 50911

Known as: SCH-50911 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Acupuncture suppresses morphine self-administration through the GABA receptors
The neurobiological substrate for morphine self-administration in animals is believed to involve the dopamine system of the… Expand
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2007
2007
Effects of GABA(B) receptor agents on cocaine priming, discrete contextual cue and food induced relapses.
In the present study we investigated the effects of the GABA(B) receptor antagonist (2S)-(+)-5,5-dimethyl-2-morpholineacetic acid… Expand
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2004
2004
Acupuncture-mediated inhibition of ethanol-induced dopamine release in the rat nucleus accumbens through the GABAB receptor
Clinical trials are currently underway to determine the effectiveness of acupuncture in the treatment of drug abuse. However… Expand
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2004
2004
Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices.
In electrically stimulated rat neocortical brain slices preloaded with [3H]gamma-aminobutyric acid (GABA) or [3H]glutamic acid… Expand
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Highly Cited
2001
Highly Cited
2001
Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons.
The striatum is a crucial site of action for the motor effects of cannabinoids (CBs). However, the electrophysiological… Expand
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2001
2001
Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid.
The present study was aimed at identifying the receptor systems involved in the mediation of the sedative/hypnotic effect of… Expand
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1999
1999
Activation of nigral dopamine neurons by the selective GABAB-receptor antagonist SCH 50911
Summary. Previous studies have shown that systemic as well as local administration of the GABAB-receptor agonist baclofen is… Expand
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Highly Cited
1999
Highly Cited
1999
Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus.
Kainate (KA) receptor activation depresses stimulus-evoked gamma-aminobutyric acid (GABA-mediated) synaptic transmission onto CA1… Expand
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1995
1995
The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.
Experiments were conducted to characterize the pharmacology of SCH 50911 ((+)-5,5-dimethyl-2-morpholineacetic acid hydrochloride… Expand
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1995
1995
Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.
Recent studies have shown that gamma-aminobutyric acidB (GABAB) receptor antagonists suppress absence seizures in animal models… Expand
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