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SCH 50911

Known as: SCH-50911 
 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Effects of GABAB receptor ligands in animal tests of depression and anxiety.
Preclinical evidence strongly implicates GABA(B) receptors in the pathophysiology of several psychiatric disorders including… Expand
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2006
2006
Beta and Gamma Range EEG Power‐Spectrum Correlation with Spiking Discharges in DBA/2J Mice Absence Model: Role of GABAB Receptors
Summary:  Purpose: To describe the correlations between spiking pattern and EEG power spectrum frequency in DBA/2J mice, a model… Expand
2002
2002
Proconvulsive effect of the GABA(B) receptor antagonist, SCH 50911, in rats undergoing ethanol withdrawal syndrome.
The present study investigated the effect of the GABA(B) receptor antagonist, SCH 50911 [(2S)(+)-5,5-dimethyl-2-morpholineacetic… Expand
Highly Cited
2001
Highly Cited
2001
Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons
1 The striatum is a crucial site of action for the motor effects of cannabinoids (CBs). However, the electrophysiological… Expand
2000
2000
Presynaptic inhibition by muscimol through GABAB receptors
The γ‐aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities… Expand
1999
1999
Activation of nigral dopamine neurons by the selective GABAB-receptor antagonist SCH 50911
Summary. Previous studies have shown that systemic as well as local administration of the GABAB-receptor agonist baclofen is… Expand
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Highly Cited
1999
Highly Cited
1999
Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus.
Kainate (KA) receptor activation depresses stimulus-evoked gamma-aminobutyric acid (GABA-mediated) synaptic transmission onto CA1… Expand
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Highly Cited
1998
Highly Cited
1998
Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by γ-hydroxybutyric acid (GHBA) are specifically induced by activation of GABAB receptors
Abstract Previous studies have shown that administration of γ-hydroxybutyric acid (GHBA) or the GABAB receptor agonist baclofen… Expand
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Highly Cited
1995
Highly Cited
1995
The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.
Experiments were conducted to characterize the pharmacology of SCH 50911 ((+)-5,5-dimethyl-2-morpholineacetic acid hydrochloride… Expand
Highly Cited
1995
Highly Cited
1995
Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.
Recent studies have shown that gamma-aminobutyric acidB (GABAB) receptor antagonists suppress absence seizures in animal models… Expand
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