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SC 8109

Known as: SC-8109 
National Institutes of Health

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2 relations

Broader (1)

Spironolactone
analogs & derivatives

Papers overview

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1962
1962
Studies on the inotropic action of aldosterone on isolated cardiac tissue preparations; including the effects of pH, ouabain and SC-8109.
The inotropic action of aldosterone on various in vitro cardiac preparations was investigated. The results obtained are presented… 
1962
1962
Über den Einfluß eines Aldosteron-Antagonisten (SC-8109) auf die Resorption von Natrium aus dem Magen-Darmtrakt von Ratten
ZusammenfassungEs konnte in tierexperimentellen Untersuchungen (40 Ratten) gezeigt werden, daß Adrenalektomie (Wegfall der… 
1961
1961
Effect of chlorothiazide and hydrochlorothiazide on blood pressure and thyroid activity of hypertensive rats.
1960
1960
Stop Flow Analysis of Aldosterone and Steroidal Antagonist SC-8109 on Renal Tubular Sodium Transport Kinetics.∗
Summary In normal dogs the distal tubule can lower Na concentration almost to zero during stop flow, the minimal concentration… 
1960
1960
The effect of sodium loading and depletion on muscular strength and aldosterone excretion in familial periodic paralysis.
1960
1960
Effects of a spirolactone (SC-8109) in primary mineralocorticoid excess.
ABSTRACT The aldosterone antagonist, SC-8109, was administered to a patient with clinical and biochemical evidence suggesting… 
1960
1960
Acute effects of corticosteroid mixtures and the 17-spirolactone SC-8109 on sodium, potassium, and water excretion in adrenalectomized, water-loaded rats.
Multiple interrelationships of cortisol and corticosterone, aldosterone and DCA, and the 17-spirolactone, SC-8109, on water and… 
1960
1960
Antiarrhythmic Activity of Various Steroidal Spirolactones in Dogs
  • C. M. Mokler
  • Proceedings of the Society for Experimental…
  • 1960
  • Corpus ID: 36379393
Summary The effects of SC-8109, or 3-(3 − oxo − 17β - hydroxy − 19 - nor − 4 - androsten-17α-yl) propanoic acid lactone, and 5… 
1960
1960
Effect of Aldosterone Antagonist on in vitro Production of Aldosterone and Corticosterone in Rats.∗
Summary Male and female Sprague-Dawley rats were treated with the spirolactone, SC-8109, known to be an aldosterone antagonist… 
1959
1959
Relationship between diuretic and antihypertensive effects of chlorothiazide and mercurial diuretics.
Both chlorothiazide and parenteral mercurial diuretics have an antihypertensive as well as a natriuretic action. Previous… 
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