• Publications
  • Influence
Pharmacologic consequences of cholesterol absorption inhibition: alteration in cholesterol metabolism and reduction in plasma cholesterol concentration induced by the synthetic saponin beta-tigogenin
TLDR
Results indicate that inhibition of cholesterol absorption by tiqueside produces profound effects on cholesterol metabolism without affecting bile acid metabolism, and that these changes lead to reductions primarily in plasma non-HDL cholesterol concentrations. Expand
The use of Rauwolfia serpentina in hypertensive patients.
TLDR
Rauwolfia serpentina has been used in India for many years to treat a variety of diseases that at first thought appear to bear little similarity to one another, but on reflection these various diseases could have a common denominator if they were all relieved symptomatically by a sedative or a "relaxing" drug such as Rau wolfia. Expand
THE NATURE OF CIRCULATORY COLLAPSE INDUCED BY SODIUM NITRITE.
Comparison of synthetic saponin cholesterol absorption inhibitors in rabbits: evidence for a non-stoichiometric, intestinal mechanism of action.
TLDR
The data indicate that pamaqueside and tiqueside induce hypocholesterolemia by blocking lumenal cholesterol absorption via a mechanism that apparently differs from the stoichiometric complexation of cholesterol hypothesized for other saponins. Expand
Clinical usage of Rauwolfia alkaloids, including reserpine (serpasil).
  • R. Wilkins
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 April 1954
Blood Pressure Responses to the Valsalva Maneuver in Cardiac Patients with and without Congestive Failure
TLDR
Experimental and clinical observations in patients indicate that this "failure response" is due to elevation of the right ventricular diastolic pressure, which interferes with the normal obstruction of venous return during the blowing effort of the Valsalva maneuver. Expand
New drug therapies in arterial hypertension.
  • R. Wilkins
  • Medicine
  • Annals of internal medicine
  • 1 December 1952
TLDR
Drugs and procedures for the treatment of essential hypertension of necessity must be nonspecific in nature, since the etiology of this disease is unknown. Expand
CHLOROTHIAZIDE IN HYPERTENSION: STUDIES ON ITS MODE OF ACTION
TLDR
Turning from a mere affirmation of the drug’s hypotensive power to an examination of its mode of action, it has been reported that chlorothiazide was potent not only in combination with other drugs, but also alone. Expand
The effect of peripheral vasomotor activity on systolic arterial pressure in the extremities of man
TLDR
It is demonstrated that systolic arterial pressure in the extremities may show considerable variations as the result of local vasomotor changes, and that such variations in peripheral pressure are independent of and at times opposite to alterations in systemic pressure as measured in more central arteries. Expand
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