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SB 415286

Known as: SB-415286, SB415286 
 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal.
The ability of exercise to decrease fat mass and increase bone mass may occur through mechanical biasing of mesenchymal stem… Expand
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Highly Cited
2008
Highly Cited
2008
Lithium Treatment Decreases Activities of Tau Kinases in a Murine Model of Senescence
Lithium modulates glycogen synthase kinase 3β (GSK-3β), a kinase involved in Alzheimer disease-related tau pathology. To… Expand
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Highly Cited
2006
Highly Cited
2006
Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells.
In addition to 17beta-estradiol binding, estrogen receptor (ER) transcriptional activity could be controlled by intracellular… Expand
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Highly Cited
2005
Highly Cited
2005
GSK-3β inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat*
Objective:Serine-threonine protein kinase glycogen synthase kinase (GSK)-3 is involved in regulation of many cell functions, but… Expand
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Highly Cited
2005
Highly Cited
2005
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
The mammalian target of rapamycin is a serine-threonine kinase that regulates cell cycle progression. Rapamycin and its analogues… Expand
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Highly Cited
2004
Highly Cited
2004
Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth
The transcriptional activity of the androgen receptor (AR) is regulated by interaction with various coregulators, one of which is… Expand
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Highly Cited
2002
Highly Cited
2002
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
Glycogen synthase kinase (GSK)-3 is a serine/threonine kinase that has been implicated in several aspects in embryonic… Expand
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Highly Cited
2001
Highly Cited
2001
Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression
A major action of insulin is to regulate the transcription rate of specific genes. The expression of these genes is dramatically… Expand
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Highly Cited
2001
Highly Cited
2001
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.
The phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (PKB; also known as Akt) signalling pathway is recognized as… Expand
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Highly Cited
2000
Highly Cited
2000
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
BACKGROUND Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the activity of which is inhibited by a… Expand
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