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SB 415286

Known as: SB-415286, SB415286 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal.
The ability of exercise to decrease fat mass and increase bone mass may occur through mechanical biasing of mesenchymal stem… 
Highly Cited
2008
Highly Cited
2008
Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation
Glycogen biogenesis and its response to physiological stimuli have often been implicated in age‐related diseases. However, their… 
Highly Cited
2008
Highly Cited
2008
Lithium Treatment Decreases Activities of Tau Kinases in a Murine Model of Senescence
Lithium modulates glycogen synthase kinase 3β (GSK-3β), a kinase involved in Alzheimer disease-related tau pathology. To… 
Highly Cited
2005
Highly Cited
2005
GSK-3β inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat*
Objective:Serine-threonine protein kinase glycogen synthase kinase (GSK)-3 is involved in regulation of many cell functions, but… 
Highly Cited
2005
Highly Cited
2005
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
The mammalian target of rapamycin is a serine-threonine kinase that regulates cell cycle progression. Rapamycin and its analogues… 
Highly Cited
2004
Highly Cited
2004
Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth
The transcriptional activity of the androgen receptor (AR) is regulated by interaction with various coregulators, one of which is… 
Highly Cited
2002
Highly Cited
2002
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
Glycogen synthase kinase (GSK)-3 is a serine/threonine kinase that has been implicated in several aspects in embryonic… 
Highly Cited
2001
Highly Cited
2001
Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression
A major action of insulin is to regulate the transcription rate of specific genes. The expression of these genes is dramatically… 
Highly Cited
2001
Highly Cited
2001
GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity
Highly Cited
2000
Highly Cited
2000
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
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