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SB 415286

Known as: SB-415286, SB415286 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2018
0520002018

Papers overview

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2010
2010
Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation.
Connexins are a large family of proteins that form gap junction channels allowing exchange of ions and small metabolites between… (More)
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2009
2009
A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286
Pharmacological GSK-3 inhibitors are potential drugs for the treatment of neurodegenerative diseases, cancer and diabetes. We… (More)
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Highly Cited
2008
Highly Cited
2008
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal.
The ability of exercise to decrease fat mass and increase bone mass may occur through mechanical biasing of mesenchymal stem… (More)
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2005
2005
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
The mammalian target of rapamycin is a serine-threonine kinase that regulates cell cycle progression. Rapamycin and its analogues… (More)
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2005
2005
GSK-3beta inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone-treated myotubes.
Sepsis is associated with muscle wasting, mainly reflecting increased muscle proteolysis. Recent studies suggest that inhibition… (More)
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2005
2005
GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat.
OBJECTIVE Serine-threonine protein kinase glycogen synthase kinase (GSK)-3 is involved in regulation of many cell functions, but… (More)
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2004
2004
Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth
The transcriptional activity of the androgen receptor (AR) is regulated by interaction with various coregulators, one of which is… (More)
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Highly Cited
2002
Highly Cited
2002
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
Glycogen synthase kinase (GSK)-3 is a serine/threonine kinase that has been implicated in several aspects in embryonic… (More)
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Highly Cited
2001
Highly Cited
2001
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.
The phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (PKB; also known as Akt) signalling pathway is recognized as… (More)
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Highly Cited
2000
Highly Cited
2000
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
BACKGROUND Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the activity of which is inhibited by a… (More)
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