Inhibiting glycogen synthase kinase 3beta in sepsis.

  title={Inhibiting glycogen synthase kinase 3beta in sepsis.},
  author={Laura Dugo and Marika Collin and David A Allen and Nimesh S. A. Patel and Inge Bauer and Eero M. A. Mervaala and Marjut Louhelainen and Simon J Foster and Muhammad Magdi Yaqoob and Christoph Thiemermann},
  journal={Novartis Foundation symposium},
  pages={128-42; discussion 142-6, 160-4}
The serine-threonine protein kinase glycogen synthase kinase (GSK)-3 is involved in the regulation of many cell functions, but its role in the regulation of the inflammatory response is unknown. Here we investigate the effects of GSK-3beta inhibition on organ injury/dysfunction caused by endotoxaemia or severe inflammation in the rat. Rats received either intravenous Escherichia coli lipopolysaccharide (LPS) (6 mg/kg) or LPS (1mg/kg) plus Staphylococcus aureus peptidoglycan (PepG) (0.3mg/kg) or… CONTINUE READING


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