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NanoLuc Reporter for Dual Luciferase Imaging in Living Animals
TLDR
NanoLuc is established as a new reporter for bioluminescence imaging studies in intact cells and living mice that will expand imaging of signal transduction in normal physiology, disease, and drug development. Expand
The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling
TLDR
The findings indicated that BUB1 functions as a kinase in the TGF-β pathway in a role beyond its established function in cell cycle regulation and chromosome cohesion, and suggest a possible point of crosstalk between the mitotic checkpoint and T GF-β signaling. Expand
Molecular Imaging of TGFβ-Induced Smad2/3 Phosphorylation Reveals a Role for Receptor Tyrosine Kinases in Modulating TGFβ Signaling
TLDR
The reporter is a dynamic, noninvasive imaging modality for monitoring TGFβ-induced Smad2 signaling in live cells and tumor xenografts and has immense potential for identifying novel effectors of R-Smad phosphorylation, for validating drug–target interaction, and for studying TGF β signaling in different metastasis models. Expand
Role of epidermal growth factor receptor degradation in cisplatin-induced cytotoxicity in head and neck cancer.
TLDR
Results show that cisplatin-induced EGFR phosphorylation and subsequent ubiquitination and degradation is an important determinant of cisPlatin sensitivity, and suggest that EGFR degradation is worth exploring as an early biomarker of response and as a target to improve outcome. Expand
Fine structure and phylogeny of green algal photobionts in the microfilamentous genus Psoroglaena (Verrucariaceae, lichen-forming ascomycetes).
TLDR
The fine structure and two molecular markers of the photobionts of P. stigonemoides and P. epiphylla were investigated to report the first report of terrestrial "prochlorophytes" of terrestrial green algae or cyanobacterial colonies. Expand
A Novel Kinase Inhibitor of FADD Phosphorylation Chemosensitizes through the Inhibition of NF-κB
TLDR
The studies described here show the utility of bioluminescent cell–based assays for the identification of active compounds and the validation of drug–target interaction in a living subject and suggest that inhibition of FADD phosphorylation is a viable target for cancer therapy. Expand
Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer
TLDR
The results implicate androgen receptor as a mediator of radioresistance in breast cancer and identify androgens receptor inhibition as a potentially effective strategy for the treatment of androgen receptors-positive radioresistant tumors. Expand
Phylogenetic analysis of LSU and SSU rDNA group I introns of lichen photobionts associated with the genera Xanthoria and Xanthomendoza (Teloschistaceae, lichenized Ascomycetes)
TLDR
The data confirm that the history of group I introns is characterized by repeated horizontal transfers, and suggests that some of these introns have ancient origins within Chlorophyta. Expand
High-Throughput Molecular Imaging for the Identification of FADD Kinase Inhibitors
TLDR
A cell-based reporter for FADD kinase activity is developed, optimized for a high-throughput screen (HTS), that measures bioluminescence in response to modulation of FADD Kinase activity in live cells. Expand
Molecular imaging of the ATM kinase activity.
TLDR
The development and validation of a novel, specific, noninvasive bioluminescent reporter that enables monitoring of ATM activity in real time, in vitro and in vivo is described. Expand
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