CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature
- Z. Miao, K. Luker, T. Schall
- Biology, MedicineProceedings of the National Academy of Sciences
- 2 October 2007
It is established that CXCR7 promotes growth of tumors formed from breast and lung cancer cells and enhances experimental lung metastases in immunodeficient as well as immunocompetent mouse models of cancer.
Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response.
- B. Moffat, T. Chenevert, B. Ross
- Medicine, PsychologyProceedings of the National Academy of Sciences…
- 12 April 2005
Overall, fDM analysis provided an early biomarker for predicting treatment response in brain tumor patients, revealing that early changes in tumor diffusion values could be used as a prognostic indicator of subsequent volumetric tumor response.
Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy.
- A. Chinnaiyan, U. Prasad, A. Rehemtulla
- Medicine, BiologyProceedings of the National Academy of Sciences…
- 15 February 2000
It is demonstrated that ionizing radiation can sensitize breast carcinoma cells to TRAIL-induced apoptosis and support for combining radiation with TRAIL to improve tumor eradication and suggest that efficacy of apoptosis-inducing cancer therapies may be monitored noninvasively, using diffusion MRI.
Diffusion magnetic resonance imaging: an early surrogate marker of therapeutic efficacy in brain tumors.
- T. Chenevert, L. D. Stegman, B. Ross
- Medicine, BiologyJournal of the National Cancer Institute
- 20 December 2000
Diffusion MRI will provide an early surrogate marker for quantification of treatment response in patients with brain tumors by detecting water diffusion changes in orthotopic 9L gliomas after doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU or carmustine).
CT-based Biomarker Provides Unique Signature for Diagnosis of COPD Phenotypes and Disease Progression
PRM is a versatile imaging biomarker capable of diagnosing disease extent and phenotype while providing detailed spatial information of disease distribution and location and its ability to differentiate between specific COPD phenotypes will allow for more accurate diagnosis of individual patients, complementing standard clinical techniques.
Ultraviolet Radiation-induced Apoptosis Is Mediated by Activation of CD-95 (Fas/APO-1)*
- A. Rehemtulla, C. Hamilton, A. Chinnaiyan, V. Dixit
- BiologyJournal of Biological Chemistry
- 10 October 1997
It is demonstrated that UV radiation can activate the Fas pathway via receptor aggregation and subsequent recruitment of the death adaptor molecule FADD/MORT1 to represent a physiologic mechanism by which UV-damaged cells are eliminated.
Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survival.
Compared with conventional neuroimaging, fDM provided an earlier assessment of equal predictive value, and the combination of fDM and RR provided a more accurate prediction of patient survival than either metric alone.
Brain cancer diagnosis and therapy with nanoplatforms.
Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells.
Evidence is provided that enzymatic steps regulating N-linked glycosylation are novel targets for developing approaches to sensitize tumor cells to cytotoxic therapies.
Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma.
- D. Hamstra, T. Chenevert, B. Ross
- MedicineProceedings of the National Academy of Sciences…
- 15 November 2005
Functional diffusion maps (fDM) provided an early biomarker for response, TTP, and OS in patients with malignant glioma and were correlated with the radiographic response, time-to-progression (TTP), and overall survival (OS).