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S 4661

Known as: S-4661 
National Institutes of Health

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Broader (1)

doripenem

Papers overview

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2007
2007
Development of an HPLC method for the determination of doripenem in human and mouse serum.
2006
2006
Delayed resistance selection for doripenem when passaging Pseudomonas aeruginosa isolates with doripenem plus an aminoglycoside.
Highly Cited
2005
Highly Cited
2005
In Vitro Activity of Doripenem (S-4661) against Multidrug-Resistant Gram-Negative Bacilli Isolated from Patients with Cystic Fibrosis
ABSTRACT Doripenem 50% inhibitory concentrations (MIC50) and 90% inhibitory concentrations (MIC90) for multidrug-resistant… 
2005
2005
Study of the synergism between carbapenems and vancomycin or teicoplanin against MRSA, focusing on S-4661, a carbapenem newly developed in Japan
S-4661 is a methylcarbapenem antibiotic newly developed in Japan. We evaluated the combined actions of carbapenems, including S… 
Highly Cited
2004
Highly Cited
2004
MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS
The Ministry of Health and Welfare, Japan banned coadministration of carbapenems, such as panipenem/betamipron (PAPM), meropenem… 
Review
2002
Review
2002
Recent developments in carbapenems
Carbapenems are β-lactam antibiotics characterised by the presence of a β-lactam ring with a carbon instead of sulfone in the 4… 
2000
2000
Comparative in vitro Activity of S-4661, a New Parenteral Carbapenem, and Other Antimicrobial Agents against Respiratory Pathogens
The activity of S-4661, a new parenteral carbapenem antibiotic, was evaluated against 202 recent clinical isolates of respiratory… 
Highly Cited
1998
Highly Cited
1998
In Vitro and In Vivo Antibacterial Activities of S-4661, a New Carbapenem
ABSTRACT The in vitro and in vivo antibacterial activities of S-4661, a new 1β-methylcarbapenem, were compared with those of… 
Highly Cited
1998
Highly Cited
1998
Application of logistic growth model to pharmacodynamic analysis of in vitro bactericidal kinetics.
A new pharmacodynamic model for the analysis of in vitro bactericidal kinetics was developed based on the logistic growth model… 
Highly Cited
1996
Highly Cited
1996
A novel 1 beta-methylcarbapenem antibiotic, S-4661. Synthesis and structure-activity relationships of 2-(5-substituted pyrrolidin-3-ylthio)-1 beta-methylcarbapenems.
The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-substituted pyrrolidin-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1… 
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