doripenem

Known as: 2-(5-sulfamoylaminomethylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylic acid, doripenem [Chemical/Ingredient] 
A broad-spectrum, carbapenem antibiotic with bactericidal and beta-lactamase resistant activities. Doripenem binds to penicillin binding proteins… (More)

Topic mentions per year

Topic mentions per year

2003-2017
020406020032017

Papers overview

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2009
2009
This study was a pharmacokinetic (PK)-pharmacodynamic (PD) target attainment analysis of doripenem. Drug concentration data in… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE Doripenem is an investigational carbapenem with broad-spectrum activity against gram-negative and gram-positive… (More)
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2008
2008
OBJECTIVE Doripenem is a new carbapenem that has broad-spectrum activity against bacterial pathogens commonly responsible for… (More)
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2006
2006
Doripenem (formerly S-4661), a parenteral carbapenem, was tested in combination with an aminoglycoside (gentamicin) to determine… (More)
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2005
2005
The spectrum of activity and potency of doripenem, a broad-spectrum parenteral carbapenem currently in clinical development, was… (More)
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2004
2004
Doripenem (formerly S-4661), a new 1-beta-methyl carbapenem, was challenged with a worldwide collection of 394 drug-refractory… (More)
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Highly Cited
2004
Highly Cited
2004
Doripenem is a broad-spectrum parenteral carbapenem under clinical development in Japan and North America. Its activities against… (More)
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2004
2004
The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of… (More)
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2004
2004
Doripenem (S-4661), a new parenteral carbapenem, was tested against over 250 clinical isolates, mutants, and transconjugants of… (More)
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2004
2004
OBJECTIVES To investigate the potency of doripenem, a broad-spectrum carbapenem characterized by a wider spectrum of activity… (More)
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