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Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway
TLDR
PML is identified as the first protein degraded by SUMO-dependent polyubiquitination, as it recruits not only RNF4, ubiquitin and proteasomes, but also many SUMOylated proteins onto PML nuclear bodies, which could physically integrate thesumOylation, ubiquItination and degradation pathways. Expand
CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae
TLDR
It is shown that the VarS/VarA two‐component sensory system comprises an additional regulatory input controlling quorum‐sensing‐dependent gene expression in V. cholerae. Expand
Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as2O3-Induced Pml or Pml/Retinoic Acid Receptor α Degradation
TLDR
It is shown that PML sumolation directly or indirectly promotes its catabolism, suggesting that mature NBs could be sites of intranuclear proteolysis and opening new insights into NB alterations found in viral infections or transformation. Expand
RUPTURED POLLEN GRAIN1, a Member of the MtN3/saliva Gene Family, Is Crucial for Exine Pattern Formation and Cell Integrity of Microspores in Arabidopsis1[C][W][OA]
TLDR
It is reported that a new gene, RUPTURED POLLEN GRAIN1 (RPG1), encodes a plasma membrane protein and is required for exine pattern formation of microspores in Arabidopsis (Arabidopsis thaliana), which exhibits severely reduced male fertility with an otherwise normal phenotype. Expand
The evolution and pathogenic mechanisms of the rice sheath blight pathogen
TLDR
The draft genome sequence of the rice sheath blight disease pathogen, R. solani AG1 IA, is assembled using next-generation Illumina Genome Analyser sequencing technologies and reveals the exclusive expression patterns of the pathogenic determinants during host infection. Expand
A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles
TLDR
VrrA is the first sRNA known to control OMV formation, and its findings suggest that VrrA contributes to bacterial fitness in certain stressful environments, and modulates infection of the host intestinal tract. Expand
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
TLDR
It is shown that retinoic acid also triggers growth arrest of leukemia-initiating cells (LICs) ex vivo and their clearance in PML-RARA mouse APL in vivo, and therapy-triggered degradation of oncoproteins could be a general strategy to eradicate cancer stem cells. Expand
Transcription factor AtMYB103 is required for anther development by regulating tapetum development, callose dissolution and exine formation in Arabidopsis.
TLDR
It is implicate that AtMYB103 plays an important role in tapetum development, callose dissolution and exine formation in A. thaliana anthers. Expand
Genome-scale identification and analysis of LEA genes in rice (Oryza sativa L.)
TLDR
Two conserved motifs CACGTA and CACGCACG were found to be overrepresented in the 1 kb upstream regions of the ABA-induced and drought-induced LEA genes. Expand
A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing.
TLDR
A key role for PrtV is demonstrated in V. cholerae interaction with grazing predators, and Caenorhabditis elegans is established as a convenient organism for identification of V. Cholerae factors involved in host interactions and environmental persistence. Expand
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