Retinoic Acid Receptor RXR-Alpha

Known as: Retinoid X Receptor A, Retinoid X Receptor Alpha, Nuclear Receptor Subfamily 2 Group B Member 1 
Retinoic acid receptor RXR-alpha (462 aa, ~51 kDa) is encoded by the human RXRA gene. This protein is involved in both binding to 9-cis retinoic acid… (More)
National Institutes of Health

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Adipocytokine Signaling PathwayBiologic DevelopmentCARM1 Transcription Regulation PathwayCell Differentiation process
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Retinoid X Receptor alpha

Papers overview

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Highly Cited
2012
Highly Cited
2012
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor… (More)
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Highly Cited
2011
Highly Cited
2011
Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
OBJECTIVE Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet… (More)
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Highly Cited
2007
Highly Cited
2007
RXR is an essential component of the oncogenic PML/RARA complex in vivo.
Although PML-enforced RARA homodimerization allows PML/RARA to bind DNA independently of its coreceptor RXR, the latter was… (More)
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Highly Cited
2006
Highly Cited
2006
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.
Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates many genes that are preferentially expressed in liver. Mice lacking… (More)
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2004
2004
Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells.
Retinoic acid receptor alpha (RARalpha) plays an important role in mediating all-trans retinoic acid (ATRA) signals. In this… (More)
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Highly Cited
2002
Highly Cited
2002
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump.
The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate-dependent transport of bile salts across the… (More)
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Highly Cited
2000
Highly Cited
2000
Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting of vitamin D receptors.
The vitamin D receptor (VDR) acts as heterodimer with the retinoid X receptor alpha (RXR) to control transcriptional activity of… (More)
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1999
1999
Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer…
Four candidate retinoid antagonists (LE135, LE511, LE540, and LE550) were designed on the basis of the ligand superfamily concept… (More)
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Highly Cited
1997
Highly Cited
1997
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.
Induction of terminal differentiation represents a promising therapeutic approach to certain human malignancies. The peroxisome… (More)
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1994
1994
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa
 
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