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Retinoid X Receptor alpha

Known as: RXR alpha Receptor, Receptor, RXR alpha, Retinoid X Receptor alpha [Chemical/Ingredient] 
A nuclear transcription factor. Heterodimerization with PPAR GAMMA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES.
National Institutes of Health

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In BloodProcess of secretionRXRA geneRXRA wt Allele

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Retinoic Acid Receptor RXR-Alpha

Papers overview

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2009
2009
Unveiling a New Essential Cis Element for the Transactivation of the CYP3A4 Gene by Xenobiotics
Pregnane X receptor (PXR) has been shown to form a heterodimer with retinoid X receptor α (RXRα) and to bind to the distal… 
Highly Cited
2006
Highly Cited
2006
Coordinate Transcriptional Repression of Liver Fatty Acid-binding Protein and Microsomal Triglyceride Transfer Protein Blocks Hepatic Very Low Density Lipoprotein Secretion without Hepatosteatosis*
Unlike the livers of humans and mice, and most hepatoma cells, which accumulate triglycerides when treated with microsomal… 
Highly Cited
2006
Highly Cited
2006
Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260.
As the obligate heterodimer partner to class II nuclear receptors, the retinoid X receptor alpha (RXRalpha) plays a vital… 
2003
2003
Involvement of retinoid X receptor alpha in coenzyme Q metabolism.
The nuclear retinoid X receptor alpha (RXRalpha) is the heterodimer partner in several nuclear receptors, some of them regulating… 
2001
2001
Dual DNA-binding specificity of peroxisome-proliferator-activated receptor gamma controlled by heterodimer formation with retinoid X receptor alpha.
The peroxisome-proliferator-activated receptor gamma (PPARgamma) is a member of the steroid/thyroid nuclear receptor superfamily… 
2000
2000
Peroxisome proliferator-activated receptor alpha-mediated pathways are altered in hepatocyte-specific retinoid X receptor alpha-deficient mice.
Retinoid x receptor alpha (RXRalpha) serves as an active partner of peroxisome proliferator-activated receptor (PPARalpha). In… 
1998
1998
Gene transcription of the retinoid X receptor alpha (RXRalpha) is regulated by fatty acids and hormones in rat hepatic cells.
This work describes the molecular mechanisms of fatty acid and hormonal modulations of the retinoid X receptor alpha (RXRalpha… 
Highly Cited
1997
Highly Cited
1997
Heterodimeric interaction between retinoid X receptor alpha and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation
OR1 is a member of the steroid/thyroid hormone nuclear receptor superfamily which has been described to mediate transcriptional… 
Highly Cited
1995
Highly Cited
1995
Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.
We have recently characterized a cardiac model of ventricular chamber defects in retinoid X receptor alpha (RXR alpha) homozygous… 
Highly Cited
1993
Highly Cited
1993
Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding.
The three-dimensional solution structure of the DNA binding domain (DBD) of the retinoid X receptor alpha (RXR alpha) was… 
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