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Retinoblastoma Protein

Known as: prb, RB1, Retinoblastoma Protein [Chemical/Ingredient] 
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell… Expand
National Institutes of Health

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Highly Cited
1998
Highly Cited
1998
The retinoblastoma protein (Rb) silences specific genes that are active in the S phase of the cell cycle and which are regulated… Expand
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Highly Cited
1998
Highly Cited
1998
The retinoblastoma protein (pRb) acts to constrain the G1-S transition in mammalian cells. Phosphorylation of pRb in G1… Expand
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Review
1996
Review
1996
Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly… Expand
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Highly Cited
1996
Highly Cited
1996
Rb protein is a critical regulator of entry into the cell cycle, and loss of Rb function by deletions, mutations, or interaction… Expand
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Highly Cited
1995
Highly Cited
1995
D-TYPE cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the Gl phase of the… Expand
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Highly Cited
1995
Highly Cited
1995
INACTIVATION of tumour-suppressor genes leads to deregulated cell proliferation and is a key factor in human tumorigenesis. Both… Expand
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Highly Cited
1993
Highly Cited
1993
The retinoblastoma protein (pRb) functions as a regulator of cell proliferation and in turn is regulated by cyclin-dependent… Expand
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Highly Cited
1992
Highly Cited
1992
The retinoblastoma susceptibility gene (RB) product, the retinoblastoma protein (pRb), functions as a regulator of cell… Expand
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Highly Cited
1989
Highly Cited
1989
Deletions or mutations of the retinoblastoma gene, RB1, are common features of many tumors and tumor cell lines. Recently, the… Expand
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Highly Cited
1989
Highly Cited
1989
The E7 proteins encoded by the human papillomaviruses (HPVs) associated with anogenital lesions share significant amino acid… Expand
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