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Retinoblastoma Protein

Known as: prb, RB1, Retinoblastoma Protein [Chemical/Ingredient] 
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell… 
National Institutes of Health

Related topics

Related topics

40 relations
BTG Cell Cycle Regulation PathwayCell CycleCell Cycle ControlCell Cycle Progression Pathway

Broader (2)

Nuclear ProteinsTumor Suppressor Proteins

Narrower (3)

Rbf protein, DrosophilaRetinoblastoma Nuclear Phosphoprotein p105-Rbretinoblastoma protein p95

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2000
Review
2000
Cell transformation by the E7 oncoprotein of human papillomavirus type 16: interactions with nuclear and cytoplasmic target proteins.
Highly Cited
2000
Highly Cited
2000
Expression of p57(KIP2) potently blocks the growth of human astrocytomas and induces cell senescence.
Highly Cited
1999
Highly Cited
1999
Alteration of pRb/p16/cdk4 regulation in human osteosarcoma
Cell‐cycle regulation depends on a fine balance between cyclin‐cyclin‐dependent kinase complexes and a family of kinase… 
Highly Cited
1997
Highly Cited
1997
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis
E1A expression during adenovirus infection induces apoptosis. E1A expression causes accumulation of the p53 tumor suppressor… 
Highly Cited
1996
Highly Cited
1996
Use of Normal and Transgenic Mice to Examine the Relationship between Terminal Differentiation of Intestinal Epithelial Cells and Accumulation of Their Cell Cycle Regulators*
A spatially well organized continuum of proliferation, differentiation, and death is displayed along crypt-villus units in the… 
Highly Cited
1995
Highly Cited
1995
Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy
Although renal hypertrophy is often associated with the progressive loss of renal function, the mechanism of hypertrophy is… 
Highly Cited
1995
Highly Cited
1995
Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6 myoblast differentiation.
The activity of the E2 F-family of transcription factors is tightly linked to control of the cell cycle. p107 and p130, two… 
Highly Cited
1992
Highly Cited
1992
Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase.
Transcription of the murine thymidine kinase gene, which is coregulated with the G1/S phase transition, is activated by changing… 
Highly Cited
1991
Highly Cited
1991
Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides
Even though the retinoblastoma gene is one of the best-studied tumor suppressor genes, little is known about its functional role… 
Highly Cited
1991
Highly Cited
1991
Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products
In this report we present evidence that simian virus 40 T antigen encodes a biological activity that is functionally equivalent… 
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