Retinoblastoma Protein

Known as: pRb, RB1, Retinoblastoma Protein [Chemical/Ingredient] 
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2018
010020019752018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
The retinoblastoma protein (Rb) silences specific genes that are active in the S phase of the cell cycle and which are regulated… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The retinoblastoma protein (pRb) acts to constrain the G1-S transition in mammalian cells. Phosphorylation of pRb in G1… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Rb protein is a critical regulator of entry into the cell cycle, and loss of Rb function by deletions, mutations, or interaction… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • table 1
Is this relevant?
Highly Cited
1995
Highly Cited
1995
D-TYPE cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the Gl phase of the… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
The retinoblastoma protein (p110RB) interacts with many cellular proteins in complexes potentially important for its growth… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
The retinoblastoma gene product (Rb) can interact efficiently with two of three D-type G1 cyclins (D2 and D3) in vitro. Binding… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
The retinoblastoma susceptibility gene (RB) product, the retinoblastoma protein (pRb), functions as a regulator of cell… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Deletions or mutations of the retinoblastoma gene, RB1, are common features of many tumors and tumor cell lines. Recently, the… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
The E7 proteins encoded by the human papillomaviruses (HPVs) associated with anogenital lesions share significant amino acid… (More)
Is this relevant?