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SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells
MicroRNAs (miRNAs) are small (∼ 22-nucleotide) RNAs that in lower organisms serve important regulatory roles in development and gene expression, typically by forming imperfect duplexes with targetExpand
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SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation
DNA tumor viruses such as simian virus 40 (SV40) express dominant acting oncoproteins that exert their effects by associating with key cellular targets and altering the signaling pathways theyExpand
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Ataxia Telangiectasia-Mutated Damage-Signaling Kinase- and Proteasome-Dependent Destruction of Mre11-Rad50-Nbs1 Subunits in Simian Virus 40-Infected Primate Cells
ABSTRACT Although the mechanism of simian virus 40 (SV40) DNA replication has been extensively investigated with cell extracts, viral DNA replication in productively infected cells utilizesExpand
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Common and unique features of T antigens encoded by the polyomavirus group.
  • J. Pipas
  • Biology, Medicine
  • Journal of virology
  • 1 July 1992
Although 12 different members of the polyomavirus group have now been identified, only SV40 and PyV have been studied extensively. Whereas each member of the group shows a restricted host range,Expand
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Raw Sewage Harbors Diverse Viral Populations
ABSTRACT At this time, about 3,000 different viruses are recognized, but metagenomic studies suggest that these viruses are a small fraction of the viruses that exist in nature. We have exploredExpand
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Loss of E2F4 activity leads to abnormal development of multiple cellular lineages.
We have generated mice deficient in E2F4 activity, the major form of E2F in many cell types. Analysis of newborn pups deficient in E2F4 revealed abnormalities in hematopoietic lineage development asExpand
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T Antigens of Simian Virus 40: Molecular Chaperones for Viral Replication and Tumorigenesis
SUMMARY Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively characterized due to its relatively simple genetic organization and the ease with which its genome is manipulated.Expand
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The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.
Simian virus 40 (SV40) encodes two proteins, large T antigen and small t antigen that contribute to virus-induced tumorigenesis. Both proteins act by targeting key cellular regulatory proteins andExpand
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Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread
BackgroundDiarrhea is the third leading infectious cause of death worldwide and is estimated to be responsible for approximately 2 million deaths a year. While many infectious causes of diarrhea haveExpand
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DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication.
The amino-terminal domain of SV40 large tumor antigen (TAg) is required for efficient viral DNA replication. However, the biochemical activity associated with this domain has remained obscure. WeExpand
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