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Recombinant Tumor Necrosis Factor Family Protein

Known as: Tumor Necrosis Factor Family Protein, Tumor Necrosis Factors, tumor necrosis factor 
A recombinant therapeutic agent which is chemically identical to or similar to one of a number of endogenous tumor necrosis factor (TNF) proteins… 
National Institutes of Health

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NCIt Antineoplastic Agent TerminologyTNF geneTNF protein, humanTumor Necrosis Factor-alpha

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Recombinant Tumor Necrosis Factor-Alpha

Papers overview

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Highly Cited
2001
Highly Cited
2001
TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications.
Multiple myeloma (MM) remains incurable and novel treatments are urgently needed. Preclinical in vitro and in vivo evaluations… 
Highly Cited
1995
Highly Cited
1995
Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1
Dendritic cells (DC) in nonlymphoid organs can internalize and process foreign antigens before migrating to secondary lymphoid… 
Review
1992
Review
1992
The pathophysiology of tumor necrosis factors.
Tumor necrosis factor (TNF) came to birth in a strange way. It made its entry into the world of biology and medicine when Lloyd… 
Highly Cited
1988
Highly Cited
1988
Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages.
We tested several monokines and muramyl dipeptide (MDP) to determine whether they induce the L-arginine-dependent effector… 
Highly Cited
1987
Highly Cited
1987
Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease
Lethally irradiated mice were injected with semiallogeneic, T-depleted bone marrow cells and an amount of peripheral T… 
Highly Cited
1987
Highly Cited
1987
Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.
Stimulation of rat astrocytes in vitro by calcium ionophore A23187 and/or lipopolysaccharide results in the generation of a… 
Highly Cited
1987
Highly Cited
1987
Phase I study of recombinant tumor necrosis factor in cancer patients.
Tumor necrosis factor is a cytokine derived from activated macrophages. This agent is cytostatic and cytolytic against… 
Highly Cited
1987
Highly Cited
1987
Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells.
Myeloma cells destroy bone by producing an osteoclast-stimulating factor that has chemical and biological characteristics similar… 
Highly Cited
1987
Highly Cited
1987
The active form of tumor necrosis factor is a trimer.
Highly Cited
1985
Highly Cited
1985
Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.
Recombinant human tumor necrosis factor (TNF) was found to enhance the adherence of human peripheral blood neutrophils to human… 
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