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mTOR regulates memory CD8 T cell differentiation
Memory CD8 T cells are a critical component of protective immunity, and inducing effective memory T-cell responses is a major goal of vaccines against chronic infections and tumours. ConsiderableExpand
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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
THE receptor–ligand pairs CD28–B7 and CD40–gp39 are essential for the initiation and amplification of T-cell-dependent immune responses1,2. CD28–B7 interactions provide 'second signals' necessary forExpand
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4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses
The 4-1BB receptor is an inducible type I membrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily that is rapidly expressed on the surface of CD4+ and CD8+ T cells afterExpand
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  • Open Access
Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010
OBJECTIVE To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant RegistryExpand
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Heterologous immunity provides a potent barrier to transplantation tolerance.
Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. WeExpand
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  • Open Access
Measuring symptom experience of side‐effects of immunosuppressive drugs: the Modified Transplant Symptom Occurrence and Distress Scale
Measurement of the patients’ subjective experience of side‐effects of immunosuppressants is a critical post‐transplant outcome. This study aimed to update and validate the 45‐item Modified TransplantExpand
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Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection
Many chronic viral infections are marked by pathogen persistence and a generalized immunosuppression. The exact mechanisms by which this occurs are still unknown. Using a mouse model of persistentExpand
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Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.
Dendritic cells (DC) play a critical role in the initiation of T cell-mediated immune responses, and express costimulatory molecules that are required for optimal activation of unprimed T cells.Expand
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Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast‐enhanced MRI protocols
To retrospectively determine the incidence of nephrogenic systemic fibrosis (NSF) in patients on dialysis administered either a lower dose high‐relaxivity linear gadolinium‐chelate, gadobenateExpand
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Belatacept and Long-Term Outcomes in Kidney Transplantation.
BACKGROUND In previous analyses of BENEFIT, a phase 3 study, belatacept-based immunosuppression, as compared with cyclosporine-based immunosuppression, was associated with similar patient and graftExpand
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