Recombinant MAGE-3.1 Antigen

Known as: MAGE-3, MAGE-3.1, MAGEA3 
A recombinant tumor-specific melanoma antigen. Vaccination with recombinant MAGE-3.1 antigen may induce a host immune response against MAGE… (More)
National Institutes of Health

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3 relations
MAGEA3 geneMAGEA3 protein, humanMAGEA3 wt Allele

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Highly Cited
2013
Highly Cited
2013
The abscopal effect associated with a systemic anti-melanoma immune response.
The clearance of nonirradiated tumors after localized radiation therapy is known as the abscopal effect. Activation of an… (More)
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Highly Cited
2004
Highly Cited
2004
Vaccine-induced CD4+ T cell responses to MAGE-3 protein in lung cancer patients.
MAGE-3 is the most commonly expressed cancer testis Ag and thus represents a prime target for cancer vaccines, despite infrequent… (More)
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Highly Cited
2002
Highly Cited
2002
The Production of a New MAGE-3 Peptide Presented to Cytolytic T Lymphocytes by HLA-B40 Requires the Immunoproteasome
By stimulating human CD8(+) T lymphocytes with autologous dendritic cells infected with an adenovirus encoding MAGE-3, we… (More)
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Highly Cited
2001
Highly Cited
2001
Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.
Immunization to multiple defined tumor antigens for specific immune therapy of human cancer has thus far proven difficult… (More)
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Highly Cited
2001
Highly Cited
2001
Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinomas.
The MAGE gene is selectively expressed in cancer tissues such as melanoma or gastrointestinal carcinomas, whereas no expression… (More)
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Highly Cited
2001
Highly Cited
2001
Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.
The ability of the immune system to recognize structurally altered, amplified or aberrantly expressed proteins can be used to… (More)
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Highly Cited
2000
Highly Cited
2000
Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells.
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that can be used for vaccination purposes, to induce a… (More)
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Highly Cited
1999
Highly Cited
1999
Melanoma Cells Present a MAGE-3 Epitope to CD4+ Cytotoxic T Cells in Association with Histocompatibility Leukocyte Antigen DR11
In this study we used TEPITOPE, a new epitope prediction software, to identify sequence segments on the MAGE-3 protein with… (More)
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Highly Cited
1994
Highly Cited
1994
Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes
Human melanoma cell line MZ2-MEL expresses several antigens recognized by autologous cytolytic T lymphocyte (CTL) clones. We… (More)
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Highly Cited
1994
Highly Cited
1994
A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3.
The human MAGE-3 gene is expressed in many tumors of several histological types but it is silent in normal tissues, with the… (More)
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