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Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α(+)DC are specialized to cross-prime CD8(+) T cells and produce interleukin-12 (IL-12) that promotes… Expand
Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.
Regulatory T-cells (Treg) have been the focus of immunologic research due to their role in establishing tolerance for harmless antigens versus allowing immune responses against foes. Increased Treg… Expand
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.
Wilms tumor gene product WT1 and proteinase 3 are overexpressed antigens in acute myeloid leukemia (AML), against which cytotoxic T lymphocytes can be elicited in vitro and in murine models. We… Expand
Immunologic Monitoring of Cancer Vaccine Therapy: Results of a Workshop Sponsored by the Society for Biological Therapy
The Society for Biological Therapy held a Workshop last fall devoted to immune monitoring for cancer immunotherapy trials. Participants included members of the academic and pharmaceutical communities… Expand
Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory
- A. Okhrimenko, J. Grün, +16 authors J. Dong
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 10 June 2014
Significance Memory T cells are essential components of immunological memory. In the apparent absence of antigen, numbers of recirculating antigen-specific memory T cells dwindle, provoking the… Expand
A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS.
This study investigated the immunogenicity of Wilms tumor gene product 1 (WT1)-peptide vaccination in WT1-expressing acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients without… Expand
Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer.
- P. Ghadjar, S. Coupland, +8 authors U. Keilholz
- Journal of clinical oncology : official journal…
- 20 April 2006
PURPOSE The liver is the primary organ of metastasis in colorectal cancer (CRC). Chemokine receptor CCR6 is expressed on a subset of T cells and is associated with their migration into the liver.… Expand
Quantitative Detection of Circulating Tumor Cells in Cutaneous and Ocular Melanoma and Quality Assessment by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
- U. Keilholz, P. Goldin-Lang, +7 authors E. Thiel
- Medicine, Biology
- Clinical Cancer Research
- 1 March 2004
Purpose: Inconsistent reports on the detection of melanoma cells in peripheral blood by reverse transcriptase-PCR (RT-PCR) have resulted in uncertainty on the prognostic value of circulating melanoma… Expand
CCN1: a novel inflammation-regulated biphasic immune cell migration modulator
- M. Loebel, S. Bauer, +9 authors C. Scheibenbogen
- Medicine, Biology
- Cellular and Molecular Life Sciences
- 20 April 2012
In this study, we performed a comprehensive analysis of the effect of CCN1 on the migration of human immune cells. The molecule CCN1, produced by fibroblasts and endothelial cells, is considered as… Expand
Surface Phenotype Analysis of Human Monocyte to Macrophage Maturation
- R. Andreesen, W. Brugger, +4 authors G. Löhr
- Biology, Medicine
- Journal of leukocyte biology
- 1 June 1990
Cells of the mononuclear phagocyte system arise from circulating blood monocytes. Upon emigration from the vasculature, monocytes differentiate into macrophages, a process that monocytes similarly… Expand