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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
This work shows that hyperglycaemia increases the production of reactive oxygen species inside cultured bovine aortic endothelial cells and is prevented by an inhibitor of electron transport chain complex II, by an uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismutase.
Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A*
It is found that leptin increases ROS generation in BAEC in a dose-dependent manner and that its effects are additive with those of glucose, which may play an important role in the progression of atherosclerosis in insulin-resistant obese diabetic patients.
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome
It is proposed that Wolf–Hirschhorn syndrome candidate 1 (WHSC1) functions together with developmental transcription factors to prevent the inappropriate transcription that can lead to various pathophysiologies.
In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction
The first successful in vivo transfer of NFκB decoy oligodeoxynucleotides to reduce the extent of myocardial infarction following reperfusion is reported, providing a new therapeutic strategy for myocardia infarctions.
Hepatocyte growth factor gene therapy of liver cirrhosis in rats
In a rat model of lethal liver cirrhosis produced by dimethylnitrosamine administrations, repeated transfections of the human HGF gene into skeletal muscles induced a high plasma level of human as well as enodogenous rat HGF, and tyrosine phosphorylation of the c–Met/HGF receptor suppressed the increase of transforming growth factor–β1 and produced the complete resolution of fibrosis in the cirrhotic liver.
Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia.
It is documents that a single intraluminal molecular delivery of combined cdc2 kinase and PCNA antisense ODNs results in a sustained inhibition of neointima formation in the rat carotid balloon-injury model.
Circulating Bone Marrow‐Derived Osteoblast Progenitor Cells Are Recruited to the Bone‐Forming Site by the CXCR4/Stromal Cell‐Derived Factor‐1 Pathway
It is demonstrated for the first time that the MOPCs were mobilized from intact bones to transiently occupy approximately 80% of the mononuclear cell population in the circulating blood by BMP‐2‐pellet implantation.
Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells
Brown adipocytes can differentiate from white fat progenitor cells in mice exposed to cold or β3-adrenergic stimulation, and this process is regulated by a microRNA that regulates the expression of
Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene.
Direct evidence is provided that NO is an endogenous inhibitor of vascular lesion formation in vivo (by inhibiting smooth muscle cell proliferation and migration) and the possibility of ec-NOS transfection as a potential therapeutic approach to treat neointimal hyperplasia is suggested.
Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
Transfected glomerulonephritic rats showed a significant reduction in levels of glomerular TGF–β1 mRNA and TGF-β1 protein, extracellular matrix accumulation and proteinuria, demonstrating the potential of gene therapy as a novel treatment for fibrotic diseases caused by TGF –β1.