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Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
Results from clinical protocols using Tr1 cells to modulate immune responses in vivo in autoimmunity, transplantation, and chronic inflammatory diseases will undoubtedly prove the biological relevance of these cells in immunotolerance. Expand
Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas.
Patients with ocular adnexal lymphoma had a high prevalence of C. psittaci infection in both tumor tissue and PBMCs, as was supported by the clinical responses observed in this study with C. Psittaci-eradicating antibiotic therapy. Expand
Prognostic Mutations in Myelodysplastic Syndrome after Stem‐Cell Transplantation
Genetic profiling revealed that molecular subgroups of patients undergoing allogeneic hematopoietic stem‐cell transplantation for MDS may inform prognostic stratification and the selection of conditioning regimen. Expand
High Frequencies of Naive Melan-a/Mart-1–Specific Cd8+ T Cells in a Large Proportion of Human Histocompatibility Leukocyte Antigen (Hla)-A2 Individuals
High frequencies of naive Melan-A–specific CD8+ T cells can be found in a large proportion of HLA-A*0201+ individuals, and as demonstrated for one patient followed over time, dramatic phenotype changes of circulating Melan–A-specific cells can occur in vivo. Expand
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.
Infusion of TK-cells might be effective in accelerating immune reconstitution, while controlling GVHD and protecting patients from late mortality in those who are candidates for haploidentical stem-cell transplantation. Expand
Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44.
BONE marrow from unrelated donors is increasingly being transplanted for the treatment of patients with leukemia, aplastic anemia, and lethal congenital disorders of hematopoiesis and immunologicExpand
Common and well-documented HLA alleles: 2012 update to the CWD catalogue.
The CWD catalogue will be updated on a regular basis moving forward, and will incorporate changes to the IMGT/HLA Database as well as empirical data from the histocompatibility and immunogenetics community. Expand
A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation.
It is shown that HLA-DPB1*0901 encodes a T-cell epitope shared by a subset of DPB1 alleles that determines nonpermissive mismatches for HSC transplantation, suggesting that biologic characterization of in vivo alloreactivity can be a tool for definition of clinically relevantnonpermissive HLA mismatching for unrelated HSC transplation. Expand
Cytokine-induced killer cells are terminally differentiated activated CD8 cytotoxic T-EMRA lymphocytes.
It is demonstrated that CIK are terminally differentiated CD8 T cells that derive from proliferating CD3(+)CD56(-)CD8(-) T cells, which coincides almost exactly with that described for the T RA(+) effector memory CD27 single positive subset of terminally differentiation human memory T cells. Expand
Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
A retrospective study compared outcomes between permissive and non-permissive HLA-DPB1 mismatches in unrelated-donor haemopoietic-cell transplantation to identify mismatches that might be tolerated and those that would increase risks after transplantation. Expand