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Receptors, Interleukin-8

Known as: Interleukin-8 Receptor, IL-8 Receptors, Receptors, IL8 
Cell surface receptors that are specific for INTERLEUKIN-8. Two specific receptor subtypes (type A and B) have been found and bind IL-8 with high… 
National Institutes of Health

Related topics

Related topics

14 relations
C-X-C Chemokine Receptor Type 1, humanC-X-C Chemokine Receptor Type 2, humanChemotaxisCytokine Receptor Gene

Papers overview

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Review
2000
Review
2000
Role of interleukin-8 in neutrophil signaling.
Interleukin-8 was originally discovered as one of the first chemokines activating neutrophil granulocytes (neutrophils) after… 
Highly Cited
2000
Highly Cited
2000
Interleukin 8 Receptor Deficiency Confers Susceptibility to Acute Experimental Pyelonephritis and May Have a Human Counterpart
Neutrophils migrate to infected mucosal sites that they protect against invading pathogens. Their interaction with the epithelial… 
Highly Cited
1999
Highly Cited
1999
β-Arrestins Regulate Interleukin-8-induced CXCR1 Internalization*
The functional role of neutrophils during acute inflammatory responses is regulated by two high affinity interleukin-8 receptors… 
Highly Cited
1998
Highly Cited
1998
The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis.
OBJECTIVE Acute neutrophil-dependent inflammation is central to acute gout. Urate crystals induce different classes of neutrophil… 
Highly Cited
1997
Highly Cited
1997
CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
Highly Cited
1997
Highly Cited
1997
Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.
Cytokines mediate inflammatory responses through their receptors in the hematopoietic system. In a search for potential mediators… 
Highly Cited
1996
Highly Cited
1996
Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.
The macrophage resistance gene NRAMP1 regulates priming/activation of macrophages for enhanced TNF alpha, IL 1 beta, and MHC… 
Review
1994
Review
1994
Chemokine receptors and molecular mimicry.
Highly Cited
1993
Highly Cited
1993
Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg.
Amino acid deletion and mutagenesis experiments have indicated that the sequences Glu-Leu-Arg (ELR) preceding the first cysteine… 
Highly Cited
1992
Highly Cited
1992
High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils.
GRO alpha and neutrophil-activating peptide 2 (NAP-2), like their analog interleukin 8 (IL-8), are considered to be inflammatory… 
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