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C-X-C Chemokine Receptor Type 2, human

Known as: CDw128b, IL8RB, IL8 Receptor Type 2 
C-X-C chemokine receptor type 2 (360 aa, ~41 kDa) is encoded by the human CXCR2 gene. This protein plays a role in both chemokine binding and… 
National Institutes of Health

Related topics

Related topics

22 relations
CXCR2 geneChemokine Receptor GeneChemotaxisCytokine Receptor Gene

Broader (1)

Interleukin-8B Receptor

Papers overview

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Highly Cited
2009
Highly Cited
2009
STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction.
Neutrophil mobilization, the release of neutrophils from the bone marrow reserve into circulating blood, is important to increase… 
Highly Cited
2006
Highly Cited
2006
Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.
We have investigated whether the signaling protein phospholipase D is implicated in leukocyte cell motility. Treating… 
Highly Cited
2004
Highly Cited
2004
The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis.
Highly Cited
2003
Highly Cited
2003
Association between interleukin-8 gene alleles and human susceptibility to tuberculosis disease.
Interleukin (IL)-8 is involved in the pathogenesis of human tuberculosis (TB). However, the contribution of polymorphisms of the… 
Highly Cited
2000
Highly Cited
2000
Chemokine Receptors CXCR-1/2 Activate Mitogen-activated Protein Kinase via the Epidermal Growth Factor Receptor in Ovarian Cancer Cells*
Ovarian cancer typically disseminates widely in the abdomen, a characteristic that limits curative therapy. The mechanisms that… 
Highly Cited
1998
Highly Cited
1998
Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokines.
Analysis of endothelial cell (EC) chemokine receptor expression by RT-PCR revealed that EC essentially do not express CC… 
Highly Cited
1998
Highly Cited
1998
The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis.
OBJECTIVE Acute neutrophil-dependent inflammation is central to acute gout. Urate crystals induce different classes of neutrophil… 
Highly Cited
1996
Highly Cited
1996
Receptor Recognition and Specificity of Interleukin-8 Is Determined by Residues That Cluster Near a Surface-accessible Hydrophobic Pocket (*)
To determine the regions of interleukin-8 (IL-8) that allow high affinity and interleukin-8 receptor type 1 (IL8R1)-specific… 
Highly Cited
1994
Highly Cited
1994
Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.
Highly Cited
1992
Highly Cited
1992
Molecular evolution of the human interleukin–8 receptor gene cluster
Abstractlnterleukin–8 (IL–8) is the prototype for a family of at least eight neutrophil chemoattractants whose genes map to human… 
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