FAQ

C-X-C Chemokine Receptor Type 2, human

Known as: CDw128b, IL8RB, IL8 Receptor Type 2 
C-X-C chemokine receptor type 2 (360 aa, ~41 kDa) is encoded by the human CXCR2 gene. This protein plays a role in both chemokine binding and… (More)

Topic mentions per year

Topic mentions per year

1992-2018
051019922018

Related topics

Related topics

21 relations
CXCR2 geneChemokine Receptor GeneChemotaxisCytokine Signaling Process
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Broader (1)

Interleukin-8B Receptor

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
C-X-C Chemokine Receptor Type 2, human
Plasma membrane
Signal Transduction
inflammatory response
receptor
Immunoregulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
In this study, we examined the biological action of IL-17 on human non-small cell lung cancer (NSCLC). Although IL-17 had no… (More)
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Highly Cited
2000
Highly Cited
2000
Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines.
OBJECTIVE Human chondrocytes produce different C-X-C and C-C chemokines under basal conditions and upon activation with… (More)
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Highly Cited
2000
Highly Cited
2000
Growth Regulated Oncogene-α expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC Receptor-2 dependent mechanism
Growth Regulated Oncogene-α (GRO-α) is an autocrine growth factor in melanoma and is a member of the C-X-C family of chemokines… (More)
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2000
2000
Distribution of novel polymorphisms of the interleukin-8 and CXC receptor 1 and 2 genes in systemic sclerosis and cryptogenic fibrosing alveolitis.
OBJECTIVE To search for single-nucleotide polymorphisms in the interleukin-8 (IL-8) and IL-8 receptor CXCR-1 and CXCR-2 genes… (More)
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Highly Cited
2000
Highly Cited
2000
Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells.
Ovarian cancer typically disseminates widely in the abdomen, a characteristic that limits curative therapy. The mechanisms that… (More)
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Highly Cited
1998
Highly Cited
1998
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
Chronic macrophage-mediated inflammation is central to atherosclerosis. A role of the monocyte chemotactic and activating C-C… (More)
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Highly Cited
1998
Highly Cited
1998
Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokines.
Analysis of endothelial cell (EC) chemokine receptor expression by RT-PCR revealed that EC essentially do not express CC… (More)
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1997
1997
The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2.
The CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA… (More)
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1997
1997
Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation.
Human neutrophils undergo rapid homologous receptor desensitization following repeated stimulation with chemoattractants such as… (More)
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Highly Cited
1996
Highly Cited
1996
The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the…
Interleukin-8 (IL-8), growth-related oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2 (NAP-2), epithelial… (More)
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