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C-X-C Chemokine Receptor Type 2, human

Known as: CDw128b, IL8RB, IL8 Receptor Type 2 
C-X-C chemokine receptor type 2 (360 aa, ~41 kDa) is encoded by the human CXCR2 gene. This protein plays a role in both chemokine binding and… Expand
National Institutes of Health

Related topics

Related topics

22 relations
CXCR2 geneChemokine Receptor GeneChemotaxisCytokine Receptor Gene
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Broader (1)

Interleukin-8B Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We… Expand
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Highly Cited
2005
Highly Cited
2005
IL-17 Enhances the Net Angiogenic Activity and In Vivo Growth of Human Non-Small Cell Lung Cancer in SCID Mice through Promoting CXCR-2-Dependent Angiogenesis1
In this study, we examined the biological action of IL-17 on human non-small cell lung cancer (NSCLC). Although IL-17 had no… Expand
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Highly Cited
2004
Highly Cited
2004
The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis.
The epithelial-mesenchymal transition (EMT) is an essential component of embryonic development, tissue remodeling, and wound… Expand
Highly Cited
2000
Highly Cited
2000
Chemokine Receptors CXCR-1/2 Activate Mitogen-activated Protein Kinase via the Epidermal Growth Factor Receptor in Ovarian Cancer Cells*
Ovarian cancer typically disseminates widely in the abdomen, a characteristic that limits curative therapy. The mechanisms that… Expand
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Highly Cited
2000
Highly Cited
2000
Distribution of novel polymorphisms of the interleukin-8 and CXC receptor 1 and 2 genes in systemic sclerosis and cryptogenic fibrosing alveolitis.
OBJECTIVE To search for single-nucleotide polymorphisms in the interleukin-8 (IL-8) and IL-8 receptor CXCR-1 and CXCR-2 genes… Expand
Highly Cited
1998
Highly Cited
1998
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
Chronic macrophage-mediated inflammation is central to atherosclerosis. A role of the monocyte chemotactic and activating C-C… Expand
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Highly Cited
1998
Highly Cited
1998
Human vascular smooth muscle cells express receptors for CC chemokines.
Arteriosclerotic lesions are characterized by the accumulation of T lymphocytes and monocytes and the proliferation of intimal… Expand
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Highly Cited
1998
Highly Cited
1998
Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokines.
Analysis of endothelial cell (EC) chemokine receptor expression by RT-PCR revealed that EC essentially do not express CC… Expand
Highly Cited
1997
Highly Cited
1997
The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2.
The CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA… Expand
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Highly Cited
1992
Highly Cited
1992
Molecular evolution of the human interleukin–8 receptor gene cluster
Abstractlnterleukin–8 (IL–8) is the prototype for a family of at least eight neutrophil chemoattractants whose genes map to human… Expand
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